Therapeutic peptides in the treatment of digestive inflammation: Current advances and future prospects

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmacological research Pub Date : 2024-10-17 DOI:10.1016/j.phrs.2024.107461

Liangliang He , Aijing Li , Ping Yu , Shumin Qin , Hor-Yue Tan , Denglang Zou , Haomeng Wu , Shuai Wang

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引用次数: 0

Abstract

Digestive inflammation is a widespread global issue that significantly impacts quality of life. Recent advances have highlighted the unique potential of therapeutic peptides for treating this condition, owing to their specific bioactivity and high specificity. By specifically targeting key proteins involved in the pathological process and modulating biomolecular functions, therapeutic peptides offer a novel and promising approach to managing digestive inflammation. This review explores the development history, pharmacological characteristics, clinical applications, and regulatory mechanisms of therapeutic peptides in treating digestive inflammation. Additionally, the review addresses pharmacokinetics and quality control methods of therapeutic peptides, focusing on challenges such as low bioavailability, poor stability, and difficulties in delivery. The role of modern biotechnologies and nanotechnologies in overcoming these challenges is also examined. Finally, future directions for therapeutic peptides and their potential impact on clinical applications are discussed, with emphasis placed on their significant role in advancing medical and therapeutic practices.

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治疗消化道炎症的治疗肽：当前进展与未来展望》。

消化系统炎症是一个普遍的全球性问题，严重影响着人们的生活质量。由于治疗肽具有特定的生物活性和高度特异性，最近的研究进展凸显了治疗肽在治疗这种疾病方面的独特潜力。通过特异性地靶向参与病理过程的关键蛋白并调节生物分子功能，治疗肽为控制消化系统炎症提供了一种新颖且前景广阔的方法。本综述探讨了治疗肽在治疗消化系统炎症方面的发展历史、药理特性、临床应用和调节机制。此外，综述还探讨了治疗肽的药代动力学和质量控制方法，重点关注生物利用度低、稳定性差和给药困难等挑战。还探讨了现代生物技术和纳米技术在克服这些挑战方面的作用。最后，还讨论了治疗肽的未来发展方向及其对临床应用的潜在影响，重点是其在推动医疗和治疗实践中的重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.