Emmanuelle de Kuijper-Timmermans, Lieke Blokland, Maurits de Kuijper, Stanimira Kalaykova, M Carola Zillikens, Natasha M Appelman-Dijkstra, Koert Gooijer, Arjan Harsevoort, Guus J M Janus
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引用次数: 0
Abstract
Objective: To explore the oral health-related quality of life and its possible risk factors among adults with Osteogenesis Imperfecta using the Oral Health Impact Profile (OHIP)-49 questionnaire. Secondary objectives were to investigate the impact of self-reported Osteogenesis Imperfecta, Dentinogenesis Imperfecta, and age on various dental parameters.
Materials and methods: A cross-sectional questionnaire was distributed online to 417 Dutch adults with Osteogenesis Imperfecta at three national referral centers. Multivariate linear regression was performed to identify indicators for OHIP-49 Scores. The effect of Osteogenesis Imperfecta, Dentinogenesis Imperfecta, and age on various dental parameters was investigated using logistic regressions (p < 0.05).
Results: One hundred and fifty-five questionnaires (37.2%) were suitable for analysis. Osteogenesis Imperfecta type III was significantly associated with higher OHIP-49 scores as compared to type I. Symptoms of temporomandibular disorders, missing teeth or dentures also increased the OHIP-49 scores significantly. Osteogenesis Imperfecta type IV and increasing age were associated with missing teeth. There was a 31.94 times (95% CI: 8.56-119.13) higher odds of tooth fracture with self-reported Dentinogenesis Imperfecta.
Conclusions: Adults with Osteogenesis Imperfecta type III report a lower oral health-related quality of life compared to Osteogenesis Imperfecta type I adults.
目的使用口腔健康影响档案(OHIP)-49 问卷调查患有成骨不全症的成年人的口腔健康相关生活质量及其可能的风险因素。次要目标是调查自我报告的成骨不全症、牙本质发育不全和年龄对各种牙齿参数的影响:在三个国家转诊中心向 417 名患有成骨不全症的荷兰成年人在线发放了横断面调查问卷。进行了多变量线性回归,以确定OHIP-49评分的指标。使用逻辑回归法研究了成骨不全症、牙本质发育不全和年龄对各种牙齿参数的影响(P 结果):155份问卷(37.2%)适合用于分析。与 I 型相比,III 型成骨不全症与较高的 OHIP-49 评分明显相关。颞下颌关节紊乱、缺牙或假牙症状也会显著增加 OHIP-49 评分。成骨不全型 IV 和年龄的增加与缺牙有关。自我报告的成骨不全症患者发生牙齿折断的几率要高出31.94倍(95% CI:8.56-119.13):结论:与成骨不全 I 型成人相比,成骨不全 III 型成人的口腔健康相关生活质量较低。
期刊介绍:
Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.