Impact of Leptin-Melanocortin Pathway Genetic Variants on Weight Loss Outcomes After Endoscopic Transoral Outlet Reduction.

IF 2.9 3区医学 Q1 SURGERY

Obesity Surgery Pub Date : 2024-11-01 Epub Date: 2024-10-17 DOI:10.1007/s11695-024-07547-0

Khushboo Gala, Wissam Ghusn, Sima Fansa, Diego Anazco, Andrew C Storm, Barham K Abu Dayyeh, Andres Acosta

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引用次数: 0

Abstract

Purpose: Variants in the leptin-melanocortin pathway (LMP) are associated with severe obesity. We evaluated weight loss of patients with or without heterozygous LMP variants, with weight recurrence after Roux-en-Y gastric bypass, who underwent endoscopic transoral outlet reduction (TORe).

Materials and methods: We retrospectively reviewed patients genotyped for an LMP who had undergone TORe, classified as "carriers" or "non-carriers" of genetic variants.

Results: We included 54 patients (22 carriers, 32 non-carriers). We identified 34 genetic variants in 21 different genes in 22 patients. Total body weight loss (%TBWL) after TORe was significantly different at 9 and 12 months (12 months: 0.68 ± 7.5% vs. 9.6 ± 8.2%, p < 0.01). This difference in weight loss was present even when analyzed in subgroups of patients who had undergone tubular TORe technique, and TORe plus APC. At 3, 6, and 12 months, the percentage of carriers achieving ≥ 5% and ≥ 10% TBWL was lower than non-carriers.

Conclusions: Patients with LMP variant who underwent RYGB had decreased weight loss 1 year after undergoing TORe.

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瘦素-黑皮素通路基因变异对内窥镜经口缩口术后减肥效果的影响

目的：瘦素-黑皮素通路（LMP）变异与严重肥胖有关。我们评估了有或没有杂合LMP变异体的患者的体重减轻情况，这些患者在Roux-en-Y胃旁路术后体重复发，并接受了内镜下经口胃出口缩小术（TORe）：我们对接受 TORe 手术的 LMP 基因分型患者进行了回顾性研究，这些患者被划分为基因变异 "携带者 "或 "非携带者"：我们共纳入了 54 名患者（22 名携带者，32 名非携带者）。我们在 22 名患者的 21 个不同基因中发现了 34 个基因变异。服用 TORe 后，总体重减轻率（%TBWL）在 9 个月和 12 个月时有显著差异（12 个月：0.68 ± 7.5% vs 0.68 ± 7.5%）：12 个月：0.68 ± 7.5% vs. 9.6 ± 8.2%, p 结论：接受 RYGB 治疗的 LMP 变异患者在接受 TORe 治疗 1 年后体重减轻。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Surgery 医学-外科

CiteScore

5.80

自引率

24.10%

发文量

567

审稿时长

3-6 weeks

期刊介绍： Obesity Surgery is the official journal of the International Federation for the Surgery of Obesity and metabolic disorders (IFSO). A journal for bariatric/metabolic surgeons, Obesity Surgery provides an international, interdisciplinary forum for communicating the latest research, surgical and laparoscopic techniques, for treatment of massive obesity and metabolic disorders. Topics covered include original research, clinical reports, current status, guidelines, historical notes, invited commentaries, letters to the editor, medicolegal issues, meeting abstracts, modern surgery/technical innovations, new concepts, reviews, scholarly presentations and opinions. Obesity Surgery benefits surgeons performing obesity/metabolic surgery, general surgeons and surgical residents, endoscopists, anesthetists, support staff, nurses, dietitians, psychiatrists, psychologists, plastic surgeons, internists including endocrinologists and diabetologists, nutritional scientists, and those dealing with eating disorders.