Four-year follow-up of weight loss maintenance using electronic medical record data: The PROPEL trial.

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM

Obesity Science & Practice Pub Date : 2024-10-19 eCollection Date: 2024-10-01 DOI:10.1002/osp4.70017

Peter T Katzmarzyk, Emily F Mire, Ronald Horswell, San T Chu, Dachuan Zhang, Corby K Martin, Robert L Newton, John W Apolzan, Eboni G Price-Haywood, Dan Fort, Thomas W Carton, Kara D Denstel

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引用次数: 0

Abstract

Rationale: Short-term weight loss is possible in a variety of settings. However, long-term, free-living weight loss maintenance following structured weight loss interventions remains elusive.

Objective: The purpose was to study body weight trajectories over 2 years of intensive lifestyle intervention (ILI) and up to 4 years of follow-up versus usual care (UC).

Methods: Data were obtained from electronic medical records (EMRs) from participating clinics. Baseline (Day 0) was established as the EMR data point closest but prior to the baseline date of the trial. The sample included 111 ILI and 196 UC patients. The primary statistical analysis focused on differentiating weight loss trajectories between ILI and UC.

Results: The ILI group experienced significantly greater weight loss compared with the UC group from Day 100 to Day 700, beyond which there were no significant differences. Intensive lifestyle intervention patients who maintained ≥5% and ≥10% weight loss at 24 months demonstrated significantly greater weight loss (p < 0.001) across the active intervention and follow-up.

Conclusions: Following 24 months of active intervention, patients with ILI regained weight toward their baseline to the point where ILI versus UC differences were no longer statistically or clinically significant. However, patients in the ILI who experienced ≥5% or ≥10% weight loss at the cessation of the active intervention maintained greater weight loss at the end of the follow-up phase.

Clinical trial registration: ClinicalTrials.gov: NCT02561221.

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利用电子病历数据对减肥维持情况进行四年跟踪：PROPEL 试验。

理由：在各种情况下，短期减肥是可能的。然而，在进行结构化减肥干预后，长期、自由生活的减肥效果仍难以维持：目的：研究强化生活方式干预（ILI）2 年后的体重轨迹，以及与常规护理（UC）相比长达 4 年的随访情况：数据来自参与研究的诊所的电子病历（EMR）。基线（第 0 天）被确定为最接近但早于试验基线日期的 EMR 数据点。样本包括 111 名 ILI 患者和 196 名 UC 患者。主要统计分析的重点是区分 ILI 和 UC 的体重减轻轨迹：结果：从第 100 天到第 700 天，ILI 组的体重减轻幅度明显大于 UC 组，但两者之间没有显著差异。强化生活方式干预患者的体重在 24 个月内保持≥5% 和≥10% 的下降幅度明显更大（p 结论：强化生活方式干预患者的体重在 24 个月内保持≥5% 和≥10% 的下降幅度明显更大：经过 24 个月的积极干预后，ILI 患者的体重恢复到基线水平，ILI 与 UC 的差异在统计学或临床上不再显著。然而，在积极干预停止时体重下降≥5%或≥10%的ILI患者在随访阶段结束时体重下降幅度更大：临床试验注册：ClinicalTrials.gov：临床试验注册：ClinicalTrials.gov：NCT02561221。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Science & Practice ENDOCRINOLOGY & METABOLISM-

CiteScore

4.20

自引率

4.50%

发文量

审稿时长

29 weeks