Soluble receptors for advanced glycation endproducts are predictors of insulin sensitivity and affected by weight loss.

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
José María Moreno-Navarrete, Yenny Leal, Marisel Rosell-Díaz, José Manuel Fernández-Real
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引用次数: 0

Abstract

Background: Mice experiments have underscored the efficacy of pharmacological inhibition of advanced glycation endproducts (AGEs) through the use of soluble receptors for advanced glycation endproducts (sRAGE) in mitigating obesity-linked metabolic disruptions and insulin resistance. However, human studies have presented conflicting findings regarding the correlation between circulating sRAGE levels and insulin resistance, as well as glucose tolerance. Here, we aimed to delve deeper into the relationship between sRAGE levels and systemic insulin sensitivity.

Methods: Plasma sRAGE levels, hyperinsulinemic-euglycemic clamp, and continuous glucose monitoring were measured in two independent cross-sectional case-control studies [cohort 1 (n = 180) and cohort 2 (n = 124)]. In addition, a subgroup of 42 participants with obesity were followed for 12 months. In 14 of these participants, weight loss was achieved through bariatric surgery intervention.

Results: Our results revealed a significant association between plasma sRAGE levels and both insulin sensitivity and glycemic control parameters, even after adjustments for age, sex, and BMI. Furthermore, longitudinal analysis demonstrated that interventions aimed at weight loss led to reductions in fasting glucose and HbA1c levels, concurrently with increases in sRAGE levels.

Conclusions: These findings underscore that sRAGE levels were strongly associated with insulin sensitivity and glycemic control, suggesting a possible role of sRAGE in preserving insulin sensitivity and maintaining glycemic control, which should be confirmed in further studies.

高级糖化终产物的可溶性受体是胰岛素敏感性的预测因子,并受减肥的影响。
背景:小鼠实验表明,通过使用高级糖化终产物可溶性受体(sRAGE)对高级糖化终产物(AGEs)进行药理抑制,可有效减轻与肥胖有关的代谢紊乱和胰岛素抵抗。然而,关于循环中 sRAGE 水平与胰岛素抵抗和葡萄糖耐量之间的相关性,人类研究得出了相互矛盾的结论。在此,我们旨在深入研究 sRAGE 水平与全身胰岛素敏感性之间的关系:在两项独立的横断面病例对照研究[队列 1(n = 180)和队列 2(n = 124)]中测量了血浆 sRAGE 水平、高胰岛素血糖钳夹和连续葡萄糖监测。此外,还对 42 名肥胖症患者进行了为期 12 个月的随访。其中 14 名参与者通过减肥手术干预实现了体重减轻:结果:我们的研究结果表明,即使对年龄、性别和体重指数进行调整,血浆 sRAGE 水平与胰岛素敏感性和血糖控制参数之间仍存在明显关联。此外,纵向分析表明,旨在减轻体重的干预措施可降低空腹血糖和 HbA1c 水平,同时提高 sRAGE 水平:这些发现强调了sRAGE水平与胰岛素敏感性和血糖控制密切相关,表明sRAGE可能在保持胰岛素敏感性和维持血糖控制方面发挥作用,这一点应在进一步的研究中得到证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
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