An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infection.

IF 6.9 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2024-10-14 DOI:10.1038/s41541-024-00988-9

Shiho Chiba, Maki Kiso, Shinya Yamada, Kazuhiko Someya, Yoshikuni Onodera, Aya Yamaguchi, Satoko Matsunaga, Ryuta Uraki, Kiyoko Iwatsuki-Horimoto, Seiya Yamayoshi, Fumihiko Takeshita, Yoshihiro Kawaoka

引用次数: 0

Abstract

Highly pathogenic avian influenza (HPAI) H5 viruses from different clades have been circulating globally, threatening wild/domestic birds and mammals. Given frequent spillovers and high mortality among mammals, coupled with our inability to predict which clade of H5 virus has pandemic potential, cross-clade protective HPAI H5 vaccines are urgently needed. Here, we demonstrate the applicability of a lipid nanoparticle-based mRNA vaccine modality to induce cross-protective immunity against lethal HPAI virus infection.

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编码 H5HA 2.3.4.4b 支系的 mRNA 候选疫苗可保护小鼠免受 2.3.2.1a 支系病毒感染。

来自不同支系的高致病性禽流感 H5 病毒一直在全球流行，威胁着野生/家养鸟类和哺乳动物。鉴于哺乳动物间的频繁传播和高死亡率，再加上我们无法预测哪个支系的 H5 病毒具有大流行的潜力，因此迫切需要跨支系的高致病性禽流感 H5 保护性疫苗。在这里，我们展示了基于脂质纳米粒子的 mRNA 疫苗模式在诱导对致命性高致病性禽流感病毒感染的交叉保护性免疫方面的适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.