Health Disparities Among Sexual and Gender Minority People Living With Epilepsy: A Cross-Sectional Analysis.

IF 2.3 Q3 CLINICAL NEUROLOGY

Neurology. Clinical practice Pub Date : 2025-02-01 Epub Date: 2024-10-08 DOI:10.1212/CPJ.0000000000200379

Levi C M Barros, Caroline Banfi, Julianne D Brooks, Maria A Donahue, Aya ElHassan, Chelsea N Wong, Z Paige L'Erario, Brandy E Fureman, Jeffrey Buchhalter, Sahar Zafar, Alison Kukla, Lidia M V R Moura

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引用次数: 0

Abstract

Background and objectives: Visibility of sexual and gender minority (SGM) people has been steadily increasing over the recent years; however, little is known about the distinct seizure and mental health characteristics among SGM people with epilepsy. In this study, we describe these characteristics among SGM subgroups.

Methods: Data on demographics, seizure metrics, mental health, and quality of life were collected using patient-reported questionnaires gathered at first epilepsy clinic visits as part of routine clinical care from January 2019 to September 2023 at Massachusetts General Hospital. SGM people were defined as people who completed both sexual orientation and gender identity questionnaires and reported a sexual orientation other than heterosexual and/or a gender identity other than cisgender. Seizure control was defined as 1 year or more without experiencing seizures. Anxiety, depression, and quality-of-life data were collected through ordinal scales (GAD-7, PHQ-9, and PROMIS 10, respectively). Descriptive statistics were used to compare data between groups. No association test was performed because of the descriptive nature of this study.

Results: From 4,046 first-visit questionnaires, 2,166 (53.53%) had sexual orientation and gender identity information, with 143 (6.6%) of these respondents identified as SGM. Seizure control was present in 27 (65.85%) and 401 (62.95%) heterosexual cisgender respondents. Median values of SGM and heterosexual cisgender respondents were 5 (interquartile range [IQR] 8) and 3 (IQR 6) for PHQ-9 (depression), 4 (IQR 7) and 3 (IQR 10) for GAD-7 (anxiety), 41.1 (IQR 14.5) and 45.8 (IQR 14.5) for PROMIS-10-Mental, and 47.7 (IQR 11.8) and 50.8 (IQR 15.4) for PROMIS-10-Physical, respectively.

Discussion: This study provides one of the first overviews of distinct epilepsy, mental health, and quality-of-life metrics among SGM people. The low proportion of survey responses regarding sexual orientation and gender identity fields indicate the need for improved data collection methods in epilepsy clinics.

查看原文本刊更多论文

性与性别少数群体癫痫患者的健康差异：横断面分析。

背景和目的：近年来，性与性别少数群体（SGM）的能见度一直在稳步上升；然而，人们对 SGM 癫痫患者的独特发作和心理健康特征知之甚少。在本研究中，我们描述了 SGM 亚群的这些特征：从 2019 年 1 月到 2023 年 9 月，在马萨诸塞州总医院的常规临床护理中，我们使用患者报告的问卷调查收集了有关人口统计学、癫痫发作指标、心理健康和生活质量的数据。SGM人群被定义为同时填写了性取向和性别认同问卷，并报告了异性恋以外的性取向和/或顺性性别以外的性别认同的人群。癫痫发作控制是指 1 年或 1 年以上未出现癫痫发作。焦虑、抑郁和生活质量数据通过序数量表（分别为 GAD-7、PHQ-9 和 PROMIS 10）收集。描述性统计用于比较组间数据。由于本研究为描述性研究，因此未进行关联检验：在 4046 份初诊问卷中，2166 人（53.53%）有性取向和性别认同信息，其中 143 人（6.6%）被认定为 SGM。有 27 名（65.85%）和 401 名（62.95%）异性恋双性恋受访者存在癫痫发作控制。SGM 和异性恋双性别受访者的 PHQ-9（抑郁）中位值分别为 5（四分位距[IQR] 8）和 3（IQR 6），GAD-7（焦虑）中位值分别为 4（IQR 7）和 3（IQR 10），41.PROMIS-10-精神方面分别为 41.1（IQR 14.5）和 45.8（IQR 14.5），PROMIS-10-身体方面分别为 47.7（IQR 11.8）和 50.8（IQR 15.4）：本研究首次概述了 SGM 患者中不同的癫痫、心理健康和生活质量指标。有关性取向和性别认同领域的调查回复比例较低，这表明癫痫诊所需要改进数据收集方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology. Clinical practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

0.00%

发文量

期刊介绍： Neurology® Genetics is an online open access journal publishing peer-reviewed reports in the field of neurogenetics. The journal publishes original articles in all areas of neurogenetics including rare and common genetic variations, genotype-phenotype correlations, outlier phenotypes as a result of mutations in known disease genes, and genetic variations with a putative link to diseases. Articles include studies reporting on genetic disease risk, pharmacogenomics, and results of gene-based clinical trials (viral, ASO, etc.). Genetically engineered model systems are not a primary focus of Neurology® Genetics, but studies using model systems for treatment trials, including well-powered studies reporting negative results, are welcome.