Genetic and epigenetic alterations in aging and rejuvenation of human

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules and Cells Pub Date : 2024-10-19 DOI:10.1016/j.mocell.2024.100137

Kyunghyuk Park , Min Chul Jeon , Dakyung Lee , Jong-Il Kim , Sun-Wha Im

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引用次数: 0

Abstract

All the information essential for life is encoded within our genome and epigenome, which orchestrates diverse cellular states spatially and temporally. In particular, the epigenome interacts with internal and external stimuli, encoding and preserving cellular experiences, and it serves as the regulatory base of the transcriptome across diverse cell types. The emergence of single-cell transcriptomic and epigenomic data collection has revealed unique omics signatures in diverse tissues, highlighting cellular heterogeneity. Recent research has documented age-related epigenetic changes at the single-cell level, alongside the validation of cellular rejuvenation through partial reprogramming, which involves simultaneous epigenetic modifications. These dynamic shifts, primarily fueled by stem cell plasticity, have catalyzed significant interest and cross-disciplinary research endeavors. This review explores the genomic and epigenomic alterations with aging, elucidating their reciprocal interactions. Additionally, it seeks to discuss the evolving landscape of rejuvenation research, with a particular emphasis on dissecting stem cell behavior through the lens of single-cell analysis. Moreover, it proposes potential research methodologies for future studies.

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人类衰老和返老还童过程中的基因和表观遗传学变化。

生命所必需的所有信息都编码在我们的基因组和表观基因组中，它们在空间和时间上协调着不同的细胞状态。特别是，表观基因组与内部和外部刺激相互作用，编码和保存细胞的经验，它是不同类型细胞转录组的调控基础。单细胞转录组和表观基因组数据收集的出现揭示了不同组织中独特的表观特征，凸显了细胞的异质性。最近的研究记录了单细胞水平上与年龄相关的表观遗传变化，同时还验证了通过部分重编程实现的细胞年轻化，这涉及同时进行的表观遗传修饰。这些主要由干细胞可塑性推动的动态变化，引起了人们的极大兴趣，也促进了跨学科研究工作。这篇综述探讨了基因组和表观基因组随着衰老而发生的改变，阐明了它们之间的相互影响。此外，它还试图讨论不断发展的返老还童研究，特别强调通过单细胞分析的视角剖析干细胞行为。此外，它还为未来研究提出了潜在的研究方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecules and Cells 生物-生化与分子生物学

CiteScore

6.60

自引率

10.50%

发文量

审稿时长

2.3 months

期刊介绍： Molecules and Cells is an international on-line open-access journal devoted to the advancement and dissemination of fundamental knowledge in molecular and cellular biology. It was launched in 1990 and ISO abbreviation is "Mol. Cells". Reports on a broad range of topics of general interest to molecular and cell biologists are published. It is published on the last day of each month by the Korean Society for Molecular and Cellular Biology.