Nutritional deuterium depletion and health: a scoping review.

IF 3.5 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Metabolomics Pub Date : 2024-10-13 DOI:10.1007/s11306-024-02173-4

Nicole Korchinsky, Anne M Davis, László G Boros

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引用次数: 0

Abstract

Introduction: Large variations in fatty and amino acid natural ²H/¹H ratios in reference with solvent water point to the active involvement of compartmental, inter- and intramolecular deuterium disequilibrium in adaptive biology. Yet, the human deutenome is an untapped area of energy metabolism and health in humans.

Objectives: The purpose of this scoping review is to examine health effects through deuterium homeostasis using deuterium-depleted water and/or a deuterium-depleted diet. We also aim to reveal health effects of nutritional, metabolic and exercise ketosis, i.e. complete mitochondrial fatty acid oxidation with the production of deuterium depleted (deupleted) metabolic water.

Methods: A protocol process approach was used to retrieve current research in deuterium depletion according to the preferred reporting items protocol for systematic reviews and meta-analyses, extension for scoping reviews with checklist (PRISMA-ScR).

Results: Fifteen research articles were used. All retrieved articles were heterogenous in nature and additional themes did not evolve. Deuterium depletion was found to have beneficial health effects in the following conditions: cancer prevention, cancer treatment, depression, diabetes, long-term memory, anti-aging, and sports performance. Deutenomics is actively pursued in drug research and there are biomarker roles attributed to large natural variations with adaptive significance in biology.

Conclusion: Even with limited data, consistent deuterium depletion can be seen across all conditions reviewed. More randomized control trials are recommended to confirm cause and effect for translationally and clinically informed integrative nutrition-based medical interventions.

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营养氘耗竭与健康：范围界定综述。

导言：参照溶剂水，脂肪酸和氨基酸天然 2H/1H 比值的巨大变化表明，在适应性生物学中，区室、分子间和分子内氘不平衡的作用十分活跃。然而，人类氘组是人类能量代谢和健康的一个尚未开发的领域：本范围综述的目的是利用贫氘水和/或贫氘饮食研究氘平衡对健康的影响。我们还旨在揭示营养、代谢和运动性酮症（即线粒体脂肪酸完全氧化并产生贫氘代谢水）对健康的影响：方法：根据系统综述和荟萃分析的首选报告项目协议、范围界定综述扩展协议及核对表（PRISMA-ScR），采用协议流程法检索当前有关氘耗的研究：共使用了 15 篇研究文章。所有检索到的文章性质各异，没有形成新的主题。研究发现，氘消耗在以下方面对健康有益：癌症预防、癌症治疗、抑郁症、糖尿病、长期记忆、抗衰老和运动表现。氘组学在药物研究中得到积极探索，生物标志物的作用归因于生物学中具有适应意义的巨大自然变异：结论：即使数据有限，但在所审查的所有情况中都可以看到一致的氘耗竭。建议进行更多的随机对照试验，以确认以营养为基础的综合医疗干预措施在转化和临床上的因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolomics 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.80%

发文量

审稿时长

2 months

期刊介绍： Metabolomics publishes current research regarding the development of technology platforms for metabolomics. This includes, but is not limited to: metabolomic applications within man, including pre-clinical and clinical pharmacometabolomics for precision medicine metabolic profiling and fingerprinting metabolite target analysis metabolomic applications within animals, plants and microbes transcriptomics and proteomics in systems biology Metabolomics is an indispensable platform for researchers using new post-genomics approaches, to discover networks and interactions between metabolites, pharmaceuticals, SNPs, proteins and more. Its articles go beyond the genome and metabolome, by including original clinical study material together with big data from new emerging technologies.