Recent advancements in cGAS-STING activation, tumor immune evasion, and therapeutic implications.

IF 2.8 4区 医学 Q2 ONCOLOGY
Saiful Islam, Md Mazedul Islam, Mst Rubaiat Nazneen Akhand, Byung-Yong Park, Md Rashedunnabi Akanda
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Abstract

The cGAS-STING signaling pathway is indeed a pivotal component of the immune system and serve as a crucial link between innate and adaptive immune responses. STING is involved in the cellular response to pathogen invasion and DNA damage, and which has important consequences for host defense mechanisms and cancer regulation. Ongoing research aiming to modulate the cGAS-STING pathway for improved clinical outcomes in cancer and autoimmune diseases is underway. Indeed, the interaction between the cGAS-STING pathway and immune evasion mechanisms is a complex and critical aspect of cancer biology. Pathogens and various host factors can exploit this pathway to reduce the effectiveness of cancer therapies, particularly immunotherapies. Thus, immunotherapies or combination therapies may assist in overcoming the immune suppression and improving clinical outcomes. This review explores recent advancements in understanding the cGAS-STING signaling pathway, with particular emphasis on its activation mechanisms and role in tumor immune evasion. The dual role of the pathway in boosting immune responses while simultaneously enabling tumors to evade the immune system makes it a crucial target for innovative cancer treatment approaches.Please confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Author 2 Given name: [Md Mazedul] Last name [Islam], Author 3 Given name: [Mst Rubaiat Nazneen] Last name [Akhand] and Author 5 Given name: [Md Rashedunnabi] Last name [Akanda]. Also, kindly confirm the details in the metadata are correct.AQ1: Here Author 4 given name: [Byung-Yong] Last name [Park] is missing. Metadata are correct.

cGAS-STING 激活、肿瘤免疫逃避和治疗意义方面的最新进展。
cGAS-STING 信号通路确实是免疫系统的关键组成部分,是先天性免疫反应和适应性免疫反应之间的重要环节。STING 参与细胞对病原体入侵和 DNA 损伤的反应,对宿主防御机制和癌症调控具有重要影响。目前正在进行的研究旨在调节 cGAS-STING 通路,以改善癌症和自身免疫性疾病的临床治疗效果。事实上,cGAS-STING 通路与免疫逃避机制之间的相互作用是癌症生物学中一个复杂而关键的方面。病原体和各种宿主因素可利用这一途径来降低癌症疗法,尤其是免疫疗法的疗效。因此,免疫疗法或联合疗法可能有助于克服免疫抑制并改善临床疗效。本综述探讨了在了解 cGAS-STING 信号通路方面的最新进展,特别强调了其激活机制和在肿瘤免疫逃避中的作用。该通路在增强免疫应答的同时又能使肿瘤逃避免疫系统的双重作用,使其成为创新性癌症治疗方法的关键靶点。请确认作者姓名的表述是否准确,顺序是否正确(名字、中间名/姓氏、姓氏)。作者 2 姓名:[Md Mazedul] 姓氏[Islam],作者 3 姓名:[Mst Rubaiat Nazneen] 姓氏[Akhand],作者 5 姓名:[Md Rashedunnabi] 姓氏[Akanda]。此外,请确认元数据中的详细信息是否正确。AQ1:此处缺少作者 4 的名字:[Byung-Yong] 姓氏 [Park]。元数据正确。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medical Oncology
Medical Oncology 医学-肿瘤学
CiteScore
4.20
自引率
2.90%
发文量
259
审稿时长
1.4 months
期刊介绍: Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.
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