Increased thyroid hormone sensitivity is correlated with visceral obesity in patients with type 2 diabetes.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2024-10-16 DOI:10.1186/s12944-024-02320-9

Lu Yu, Yujia Liu, Yingxuan Wang, Gang Wang, Xianchao Xiao, Huan Wang, Hanyu Wang, Hui Sun, Guixia Wang

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引用次数: 0

Abstract

Objective: The study aimed to assess whether thyroid hormone (TH) sensitivity is related to visceral fat area (VFA) and visceral obesity in euthyroid subjects with type 2 diabetes (T2D).

Methods: 750 euthyroid patients with T2D were enrolled. A VFA of 80 cm² or more was considered visceral obesity. Central TH sensitivity was conducted using thyrotrophic thyroxine resistance index (TT4RI), thyrotropin index (TSHI), and thyroid feedback quantile-based index (TFQI). Free triiodothyronine to free thyroxine (FT3/FT4) was utilized for assessing peripheral TH sensitivity.

Results: The subjects had a mean age of 51.5 ± 11.1 years, and 540 (72.0%) of them were men. In multivariable regression analyses, there was a positive correlation of FT3/FT4 tertile with visceral obesity, after full adjustment for confounding variables (P < 0.05). The middle and highest FT3/FT4 tertiles were correlated with a 134% [95% CI (1.24, 4.44)] and 98% [95% CI (1.04, 3.78)] higher prevalence of visceral obesity than the lowest tertile, respectively. Conversely, elevated TFQI levels were linked to a decreased prevalence of visceral obesity. Stratified analysis revealed that these associations were particularly pronounced in participants who are neither overweight nor obese and those aged less than 60 years (all P < 0.05).

Conclusions: Higher TH sensitivity is correlated with visceral obesity and elevated VFA in euthyroid patients with T2D, particularly among those younger than 60 years and individuals who are neither overweight nor obese.

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甲状腺激素敏感性的增加与2型糖尿病患者的内脏肥胖有关。

研究目的该研究旨在评估甲状腺激素（TH）敏感性是否与甲状腺功能正常的 2 型糖尿病（T2D）患者的内脏脂肪面积（VFA）和内脏肥胖有关。内脏脂肪面积达到或超过 80 平方厘米被视为内脏肥胖。使用甲状腺素抵抗指数（TT4RI）、促甲状腺素指数（TSHI）和基于甲状腺反馈量子化指数（TFQI）对中枢甲状腺素敏感性进行检测。游离三碘甲状腺原氨酸对游离甲状腺素（FT3/FT4）用于评估外周甲状腺素敏感性：受试者的平均年龄为（51.5 ± 11.1）岁，其中 540 人（72.0%）为男性。在多变量回归分析中，在对混杂变量进行充分调整后，FT3/FT4三分层与内脏肥胖呈正相关（P 结论：较高的 TH 敏感性与内脏肥胖相关：在甲状腺功能正常的 T2D 患者中，较高的 TH 敏感性与内脏肥胖和 VFA 升高相关，尤其是在 60 岁以下和既不超重也不肥胖的人群中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.