A novel approach for the treatment of diabetic foot ulcers using a multimodal wound matrix: a clinical study.

IF 1.5 4区医学 Q3 DERMATOLOGY

Journal of wound care Pub Date : 2024-10-02 Epub Date: 2024-09-05 DOI:10.12968/jowc.2024.0085

Richard Simman, Suzanne J Bakewell, Desmond Bell, Susan Shuman, Mary Cheney

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引用次数: 0

Abstract

Objective: Innovation in wound healing, particularly regarding diabetic foot ulcers (DFUs), is needed to reverse the number of diabetes-related amputations. This study evaluated a novel approach and performance of a multimodal wound matrix in converting stalled DFUs into a healing trajectory.

Method: Patients with either type 1 or 2 diabetes and with foot ulcers (Wagner grade 1 and 2), were screened to determine eligibility for treatment. Ulcers improving >30% in area during a two-week screening phase were not eligible for the study treatment phase. The study was an open-label trial conducted in three phases: screening, treatment and healing confirmation. Patients enrolled in the study received a treatment protocol that included application of a wound matrix to the ulcer and offloading.

Results: A total of 19 patients (15 males, four females) with a median age of 60 years, and a median ulcer duration of 36 weeks took part in the study. Patients showed an average four-week percentage area reduction (PAR) of 62%, a 12-week PAR of 94%, and a 12-week healing rate of 57% (8/14).

Conclusion: Results of this study support the viability and potential of a novel approach to treating DFUs that includes use of a multimodal wound matrix.

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利用多模式伤口基质治疗糖尿病足溃疡的新方法：一项临床研究。

目标：伤口愈合，尤其是糖尿病足溃疡（DFUs）的愈合需要创新，以扭转糖尿病相关截肢的数量。本研究评估了一种新方法和多模式伤口基质在将停滞不前的糖尿病足溃疡转化为愈合轨迹方面的性能：方法：筛选患有 1 型或 2 型糖尿病、足部溃疡（瓦格纳 1 级和 2 级）的患者，以确定其是否符合治疗条件。在为期两周的筛查阶段，溃疡面积改善>30%的患者没有资格进入研究治疗阶段。该研究是一项开放标签试验，分三个阶段进行：筛选、治疗和愈合确认。参加研究的患者接受的治疗方案包括在溃疡处涂抹伤口基质和卸载：共有 19 名患者（15 名男性，4 名女性）参加了研究，中位年龄为 60 岁，中位溃疡持续时间为 36 周。患者的平均四周面积缩小率（PAR）为 62%，12 周面积缩小率为 94%，12 周愈合率为 57%（8/14）：这项研究的结果证明了使用多模式伤口基质治疗 DFU 的新方法的可行性和潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of wound care DERMATOLOGY-

CiteScore

2.90

自引率

10.50%

发文量

215

期刊介绍： Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.