Prevalence of elephantiasis, an overlooked disease in Southern Africa: a comprehensive review.

IF 1.8 3区 医学 Q4 TOXICOLOGY
Siphamandla Qhubekani Lamula, Elizabeth Bosede Aladejana, Emmanuel Adebowale Aladejana, Lisa Valencia Buwa-Komoreng
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引用次数: 0

Abstract

Elephantiasis, also known as lymphatic filariasis (LF), is a debilitating condition characterized by the thickening of the skin and muscles, primarily affecting the limbs, genitalia, and female breasts. Lymphatic filariasis is a major global health concern, affecting approximately 120 million people worldwide and having a significant impact on people's quality of life, mobility, and socio-economic status. Although LF is endemic in many parts of the world, including Africa, it is a neglected issue in Southern Africa, with little information available. According to the World Health Organisation, approximately 882.5 million people in 44 countries worldwide are at risk of contracting LF, making it the second most common vector-borne disease after malaria. The primary goal of this review was to assess the prevalence of elephantiasis in the Southern African Development Community (SADC) region. Lymphatic filariasis is endemic in four of the sixteen SADC countries, three countries have administered MDA to the population that required it and they are now under post-intervention surveillance, while LF is no longer a public health problem in Malawi. Global efforts to eliminate LF have been hampered by the non-availability of MDA in some SADC countries such as Angola, Mozambique, Zambia, and Zimbabwe. Despite the implementation of mass drug administration programs, a review of the literature reveals gaps in knowledge about LF prevalence cases in SADC countries. Each country faces unique challenges and successes in combating LF due to varying levels of available data and healthcare infrastructure. Some SADC countries continue to bear the burden of LF-related diseases, necessitating ongoing disease prevention and elimination efforts. This review emphasizes the importance of ongoing research, data collection, and novel policies to combat the spread of elephantiasis disease in the SADC region and beyond.

南部非洲被忽视的疾病--象皮病的流行情况:全面回顾。
象皮病又称淋巴丝虫病(LF),是一种以皮肤和肌肉增厚为特征的衰弱性疾病,主要影响四肢、生殖器和女性乳房。淋巴丝虫病是一个重大的全球健康问题,全球约有 1.2 亿人受到影响,对人们的生活质量、行动能力和社会经济地位产生了重大影响。虽然淋巴丝虫病在包括非洲在内的世界许多地方都有流行,但在南部非洲却被忽视,相关信息很少。据世界卫生组织统计,全球 44 个国家约有 8.825 亿人面临感染 LF 的风险,使其成为仅次于疟疾的第二大病媒传播疾病。本报告的主要目的是评估象皮病在南部非洲发展共同体(SADC)地区的流行情况。淋巴丝虫病在南部非洲发展共同体 16 个国家中的 4 个国家流行,3 个国家已对有需要的人群实施了 MDA,目前正在进行干预后监测,而在马拉维,淋巴丝虫病已不再是一个公共卫生问题。由于安哥拉、莫桑比克、赞比亚和津巴布韦等一些南部非洲发展共同体国家没有提供 MDA,全球消除 LF 的努力受到了阻碍。尽管实施了大规模给药计划,但文献综述显示,人们对南部非洲发展共同体国家 LF 流行病例的了解还存在差距。由于可用数据和医疗基础设施水平不同,每个国家在抗击 LF 方面都面临着独特的挑战,也取得了独特的成功。一些南部非洲发展共同体国家继续承受着 LF 相关疾病的负担,因此有必要持续开展疾病预防和消除工作。本综述强调了持续开展研究、收集数据和制定新政策以遏制象皮病在南部非洲发展共同体地区内外蔓延的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
39
审稿时长
6-12 weeks
期刊介绍: Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD) is a non-commercial academic open access publication dedicated to research on all aspects of toxinology, venomous animals and tropical diseases. Its interdisciplinary content includes original scientific articles covering research on toxins derived from animals, plants and microorganisms. Topics of interest include, but are not limited to:systematics and morphology of venomous animals;physiology, biochemistry, pharmacology and immunology of toxins;epidemiology, clinical aspects and treatment of envenoming by different animals, plants and microorganisms;development and evaluation of antivenoms and toxin-derivative products;epidemiology, clinical aspects and treatment of tropical diseases (caused by virus, bacteria, algae, fungi and parasites) including the neglected tropical diseases (NTDs) defined by the World Health Organization.
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