Prevalence of Human Papillomavirus (HPV) Infection and its Association With Pap Smear Findings Among Women Attending a Gynecology Clinic in Khorasan Razavi-Iran.

IF 1.4 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Sareh Etemad, Amir Mohammad Asghari Baghalan, Bita Naeimi, Shadi Mehrzad, Saina Adib Amin, Mohammad Soudyab, Reza Jafarzadeh Esfehani
{"title":"Prevalence of Human Papillomavirus (HPV) Infection and its Association With Pap Smear Findings Among Women Attending a Gynecology Clinic in Khorasan Razavi-Iran.","authors":"Sareh Etemad, Amir Mohammad Asghari Baghalan, Bita Naeimi, Shadi Mehrzad, Saina Adib Amin, Mohammad Soudyab, Reza Jafarzadeh Esfehani","doi":"10.34172/jrhs.2024.164","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) infection is the most common sexual transmitted disease and Pap smears and HPV testing are crucial for early detection. Advancements in HPV testing improve accuracy, but optimal screening strategies are still debated. This cross-sectional study explores HPV genotypes and predictors of infection among Iranian women undergoing gynecological screening. <b>Study Design:</b> A retrospective cross-sectional study.</p><p><strong>Methods: </strong>Women undergoing their initial cervical screening enrolled in this study. Cervical cytology samples for Pap smear analysis were collected from women referred to the genetic laboratory of Academic Center for Education Culture and Research (ACECR), Khorasan Razavi, during gynecological visits, adhering to standardized liquid-based cytology protocols. These samples were obtained over a one-year period since January 2023. Statistical analyses were conducted using SPSS version 21.0, with a significance level set at <i>P</i><0.05.</p><p><strong>Results: </strong>A total of 328 women enrolled in this study. The mean age of participants was 36±11 years and the overall HPV prevalence was 37.5% (n=123). Among HPV-positive women, nearly half (48.7%) had a single HPV genotype. Genotypes 6 (13%), 16 (12.3%), and 53 (6.7%) were the most prevalent types. Notably, high-risk HPV genotypes (16 and 18 among all) were identified in one-fourth of the study population. Women with endocervical/transformation zone cells had 25% higher odds of having HPV infection, and having mild, moderate, and severe inflammation increased the odds of having HPV infection by 14%, 11%, and 20%, respectively.</p><p><strong>Conclusion: </strong>The considerably high prevalence of HPV infection highlights the significance of HPV prevention programs in this population. Neither bacterial vaginosis nor candida infection showed a direct link to HPV positivity.</p>","PeriodicalId":17164,"journal":{"name":"Journal of research in health sciences","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492526/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of research in health sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/jrhs.2024.164","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Human papillomavirus (HPV) infection is the most common sexual transmitted disease and Pap smears and HPV testing are crucial for early detection. Advancements in HPV testing improve accuracy, but optimal screening strategies are still debated. This cross-sectional study explores HPV genotypes and predictors of infection among Iranian women undergoing gynecological screening. Study Design: A retrospective cross-sectional study.

Methods: Women undergoing their initial cervical screening enrolled in this study. Cervical cytology samples for Pap smear analysis were collected from women referred to the genetic laboratory of Academic Center for Education Culture and Research (ACECR), Khorasan Razavi, during gynecological visits, adhering to standardized liquid-based cytology protocols. These samples were obtained over a one-year period since January 2023. Statistical analyses were conducted using SPSS version 21.0, with a significance level set at P<0.05.

Results: A total of 328 women enrolled in this study. The mean age of participants was 36±11 years and the overall HPV prevalence was 37.5% (n=123). Among HPV-positive women, nearly half (48.7%) had a single HPV genotype. Genotypes 6 (13%), 16 (12.3%), and 53 (6.7%) were the most prevalent types. Notably, high-risk HPV genotypes (16 and 18 among all) were identified in one-fourth of the study population. Women with endocervical/transformation zone cells had 25% higher odds of having HPV infection, and having mild, moderate, and severe inflammation increased the odds of having HPV infection by 14%, 11%, and 20%, respectively.

Conclusion: The considerably high prevalence of HPV infection highlights the significance of HPV prevention programs in this population. Neither bacterial vaginosis nor candida infection showed a direct link to HPV positivity.

伊朗呼罗珊拉扎维妇科诊所就诊妇女的人类乳头状瘤病毒 (HPV) 感染率及其与子宫颈抹片检查结果的关联。
背景:人类乳头瘤病毒(HPV)感染是最常见的性传播疾病,而巴氏涂片和 HPV 检测对于早期检测至关重要。HPV 检测技术的进步提高了检测的准确性,但最佳筛查策略仍存在争议。本横断面研究探讨了接受妇科筛查的伊朗妇女的 HPV 基因型和感染预测因素。研究设计:回顾性横断面研究:方法:接受初次宫颈筛查的妇女参加本研究。用于巴氏涂片分析的宫颈细胞学样本是从霍拉桑拉扎维省教育文化与研究学术中心(ACECR)基因实验室转诊的妇女妇科就诊时按照标准化液基细胞学方案收集的。这些样本自 2023 年 1 月起为期一年。统计分析使用 SPSS 21.0 版进行,显著性水平设定为 PResults:共有 328 名妇女参加了本研究。参与者的平均年龄为 36±11 岁,HPV 感染率为 37.5%(n=123)。在 HPV 阳性的女性中,近一半(48.7%)有单一的 HPV 基因型。基因型 6(13%)、16(12.3%)和 53(6.7%)是最普遍的类型。值得注意的是,在四分之一的研究人群中发现了高危 HPV 基因型(其中包括 16 型和 18 型)。患有宫颈内膜/转化区细胞的妇女感染 HPV 的几率比正常妇女高 25%,而患有轻度、中度和重度炎症的妇女感染 HPV 的几率分别增加了 14%、11% 和 20%:HPV感染率相当高,这凸显了在这一人群中开展HPV预防计划的重要性。细菌性阴道病和念珠菌感染均与HPV阳性无直接关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of research in health sciences
Journal of research in health sciences PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
2.30
自引率
13.30%
发文量
7
期刊介绍: The Journal of Research in Health Sciences (JRHS) is the official journal of the School of Public Health; Hamadan University of Medical Sciences, which is published quarterly. Since 2017, JRHS is published electronically. JRHS is a peer-reviewed, scientific publication which is produced quarterly and is a multidisciplinary journal in the field of public health, publishing contributions from Epidemiology, Biostatistics, Public Health, Occupational Health, Environmental Health, Health Education, and Preventive and Social Medicine. We do not publish clinical trials, nursing studies, animal studies, qualitative studies, nutritional studies, health insurance, and hospital management. In addition, we do not publish the results of laboratory and chemical studies in the field of ergonomics, occupational health, and environmental health
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信