Evaluation of Corneal Biomechanics Using Brillouin Microscopy in Chinese Adults With Myopia.

IF 2.9 3区医学 Q1 OPHTHALMOLOGY

Journal of refractive surgery Pub Date : 2024-10-01 DOI:10.3928/1081597X-20240826-06

Jian Cao, Yanze Yu, Yong Ma, Yongle Bao, Lingling Niu, Xiaoying Wang, Xingtao Zhou, Jing Zhao

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Abstract

Purpose: To evaluate the corneal biomechanical metrics of Chinese adults with myopia and identify relevant factors of Brillouin microscopy.

Methods: In this cross-sectional study, corneal biomechanics in Chinese adults with myopia were quantified and analyzed using Brillouin microscopy and the Corvis ST (CST) (Oculus Optikgeräte GmbH) and analyzed. Univariate linear regression was used with potential factors including age, sex, spherical equivalent (SE), intraocular pressure (IOP), central corneal thickness (CCT), and mean keratometry (Kmean).

Results: The study included 87 eyes of 87 participants (mean age: 24.47 ± 6.27 years). Central, Mean, maximum (Max), minimum (Min), standard deviation, and Max-Min Brillouin modulus (BM) values obtained from Brillouin microscopy exhibited values of 2.826 ± 0.039, 2.827 ± 0.027, 2.864 ± 0.034, 2.790 ± 0.038, 0.108 ± 0.042, and 0.074 ± 0.041 GPa, respectively. No significant correlations were found between BM parameters and age, sex, SE, IOP, or CCT. However, the Mean (β = -0.251, P = .019), Min (β = -0.315, P = .003), and Max-Min (β = 0.229, P = .033) BM values were significantly associated with Kmean. The Central, Mean, Min, and Max BM values negatively correlated with the Tomographic Biomechanical Index measured by CST (Spearman's r = -0.24, -0.35, -0.29, and -0.23, respectively, all P < .05).

Conclusions: Brillouin microscopy accurately reflects corneal biomechanical parameters in Chinese adults with myopia, independent of IOP and CCT, with a good correlation with CST. Concurrent evaluation of the corneal curvature is imperative when employing Brillouin microscopy in clinical practice. [J Refract Surg. 2024;40(10):e768-e776.].

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利用布里渊显微镜评估中国成人近视患者的角膜生物力学。

目的：评估中国成年近视患者的角膜生物力学指标，并确定布里渊显微镜的相关因素：在这项横断面研究中，使用布里渊显微镜和 Corvis ST（CST）（Oculus Optikgeräte GmbH）对中国成人近视患者的角膜生物力学进行了量化和分析。采用单变量线性回归，潜在因素包括年龄、性别、球面等值（SE）、眼压（IOP）、中央角膜厚度（CCT）和平均角膜度数（Kmean）：研究包括 87 名参与者的 87 只眼睛（平均年龄：24.47 ± 6.27 岁）。通过布里渊显微镜获得的中心、平均、最大（Max）、最小（Min）、标准偏差和最大-最小布里渊模量（BM）值分别为 2.826 ± 0.039、2.827 ± 0.027、2.864 ± 0.034、2.790 ± 0.038、0.108 ± 0.042 和 0.074 ± 0.041 GPa。在 BM 参数与年龄、性别、SE、眼压或 CCT 之间没有发现明显的相关性。但是，BM 的平均值（β = -0.251，P = .019）、最小值（β = -0.315，P = .003）和最大-最小值（β = 0.229，P = .033）与 Kmean 有明显相关。中心、平均、最小和最大 BM 值与 CST 测量的断层生物力学指数呈负相关（Spearman's r = -0.24、-0.35、-0.29 和 -0.23，均 P <.05）：结论：布里渊显微镜能准确反映中国成人近视患者的角膜生物力学参数，不受眼压和角膜曲率指数（CCT）的影响，且与CST具有良好的相关性。在临床实践中使用布里渊显微镜时，必须同时评估角膜曲率。[J Refract Surg. 2024;40（10）：e768-e776]。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

$Journal of refractive surgery$

Journal of refractive surgery 医学-外科

CiteScore

5.10

自引率

12.50%

发文量

160

审稿时长

4-8 weeks

期刊介绍： The Journal of Refractive Surgery, the official journal of the International Society of Refractive Surgery, a partner of the American Academy of Ophthalmology, has been a monthly peer-reviewed forum for original research, review, and evaluation of refractive and lens-based surgical procedures for more than 30 years. Practical, clinically valuable articles provide readers with the most up-to-date information regarding advances in the field of refractive surgery. Begin to explore the Journal and all of its great benefits such as: • Columns including “Translational Science,” “Surgical Techniques,” and “Biomechanics” • Supplemental videos and materials available for many articles • Access to current articles, as well as several years of archived content • Articles posted online just 2 months after acceptance.