Potential role of calcium sulfate/β-tricalcium phosphate/graphene oxide nanocomposite for bone graft application_mechanical and biological analyses.

IF 2.8 3区医学 Q1 ORTHOPEDICS

Journal of Orthopaedic Surgery and Research Pub Date : 2024-10-12 DOI:10.1186/s13018-024-05142-8

Yung-Chang Lu, Ting-Kuo Chang, Tzu-Chiao Lin, Shu-Ting Yeh, Hung-Shih Lin, Qiao-Ping Cheng, Chun-Hsiung Huang, Hsu-Wei Fang, Chang-Hung Huang

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引用次数: 0

Abstract

Background: Bone grafts are extensively used for repairing bone defects and voids in orthopedics and dentistry. Moldable bone grafts offer a promising solution for treating irregular bone defects, which are often difficult to fill with traditional rigid grafts. However, practical applications have been limited by insufficient mechanical strength and rapid degradation.

Methods: This study developed a ceramic composite bone graft composed of calcium sulfate (CS), β-tricalcium phosphate (β-TCP) with/without graphene oxide (GO) nano-particles. The biomechanical properties, degradation rate, and in-vitro cellular responses were investigated. In addition, the graft was implanted in-vivo in a critical-sized calvarial defect model.

Results: The results showed that the compressive strength significantly improved by 135% and the degradation rate slowed by 25.5% in comparison to the control model. The addition of GO nanoparticles also improved cell compatibility and promoted osteogenic differentiation in the in-vitro cell culture study and was found to be effective at promoting bone repair in the in-vivo animal model.

Conclusions: The mixed ceramic composites presented in this study can be considered as a promising alternative for bone graft applications.

查看原文本刊更多论文

硫酸钙/β-磷酸三钙/氧化石墨烯纳米复合材料在骨移植应用中的潜在作用_力学与生物学分析

背景：骨移植被广泛用于修复整形外科和牙科中的骨缺损和空洞。可塑骨移植物为治疗不规则骨缺损提供了一种很有前景的解决方案，传统的硬质移植物通常很难填补这些缺损。然而，机械强度不足和快速降解限制了其实际应用：本研究开发了一种由硫酸钙（CS）、β-磷酸三钙（β-TCP）和/或氧化石墨烯（GO）纳米颗粒组成的陶瓷复合骨移植物。研究了其生物力学特性、降解率和体外细胞反应。此外，还在临界大小的腓骨缺损模型中植入了该移植物：结果表明，与对照模型相比，抗压强度明显提高了 135%，降解率降低了 25.5%。在体外细胞培养研究中，GO 纳米颗粒的添加还改善了细胞相容性，促进了成骨分化，并在体内动物模型中发现它能有效促进骨修复：结论：本研究提出的混合陶瓷复合材料可被视为骨移植应用的一种有前途的替代材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Orthopaedic Surgery and Research ORTHOPEDICS-

CiteScore

4.10

自引率

7.70%

发文量

494

审稿时长

>12 weeks

期刊介绍： Journal of Orthopaedic Surgery and Research is an open access journal that encompasses all aspects of clinical and basic research studies related to musculoskeletal issues. Orthopaedic research is conducted at clinical and basic science levels. With the advancement of new technologies and the increasing expectation and demand from doctors and patients, we are witnessing an enormous growth in clinical orthopaedic research, particularly in the fields of traumatology, spinal surgery, joint replacement, sports medicine, musculoskeletal tumour management, hand microsurgery, foot and ankle surgery, paediatric orthopaedic, and orthopaedic rehabilitation. The involvement of basic science ranges from molecular, cellular, structural and functional perspectives to tissue engineering, gait analysis, automation and robotic surgery. Implant and biomaterial designs are new disciplines that complement clinical applications. JOSR encourages the publication of multidisciplinary research with collaboration amongst clinicians and scientists from different disciplines, which will be the trend in the coming decades.