Decline in Isotope Dilution Space Ratio Above Age 60 Could Affect Energy Estimates Using the Doubly Labeled Water Method.

IF 3.7 3区医学 Q2 NUTRITION & DIETETICS

Journal of Nutrition Pub Date : 2024-10-15 DOI:10.1016/j.tjnut.2024.10.016

William W Wong, John R Speakman, Philip N Ainslie, Liam J Anderson, Leonore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn Vc Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G Camps, Regina Casper, Graeme L Close, Lisa H Colbert, Jamie A Cooper, Sai K Das, Peter Sw Davies, Simon Eaton, Ulf Ekelund, Catherine Hambly, Asmaa El Hamdouchi, Sonja Entringer, Barry W Fudge, Melanie Gillingham, Annelies H Goris, Micheal Gurven, Marije B Hoos, Sumei Hu, Annemiek Joosen, Peter T Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Robert F Kushner, Christel L Larsson, James C Morehen, James P Morton, Marian L Neuhouser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietilainen, Yannis P Pitsiladis, Guy Plasqui, Ross L Prentice, Roberto Rabinovich, Susan B Racette, David A Raichen, Leanne Redman, Eric Ravussin, John J Reilly, Susan Roberts, Albertine J Scuitt, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M van Etten, Edgar A Van Mil, Jeanine A Verbunt, Jonathan Ck Wells, George Wilson, Tsukasa Yoshida, Xueying Zhang, Cornelia U Loechl, Amy Luke, Alexia J Murphy-Alford, Herman Pontzer, Hiroyuki Sagayama, Jennifer C Rood, Dale A Schoeller, Klaas R Westerterp, Yosuke Yamada

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引用次数: 0

Abstract

Background: Doubly labeled water is gold standard for measuring total energy expenditure (TEE). Measurements using the method are sensitive to the isotope dilution space ratio (DSR). Accuracy and precision of the method might be improved if we could identify factors influencing DSR.

Objectives: We evaluated the potential associations of age, sex, ethnicity, anthropometry, body composition, turnover rates of the isotopes, and geographical elevation with DSR.

Methods: We used univariate regression analysis to explore the relationships between the continuous variables and analysis of variance to test the relationships between the categorical variables with DSR. Subsequently, we used general linear model (GLM) and 1-way analysis of variance to evaluate the simultaneous associations of age, sex, ethnicity, fat-free mass (FFM) and fat mass (FM) on DSR.

Results: From 5678 measurements complied from studies around the world with diverse ethnicity and living at various elevations, the mean DSR was 1.0364 ± 0.0141. No meaningful physiologic effect of any of the continuous and categorical variable on DSR was detected. General linear model analysis revealed no effect of FFM and FM (P > 0.33) on DSR, but DSR decreased with age (P < 0.001) among those aged 60 y and older regardless of sex. Among the Whites who were younger than 60 y, DSR was not related to FFM and FM (P = 0.73) but was affected by both age and sex (P < 0.001).

Conclusions: Previous estimates of age-related decline in TEE may have overestimated TEE at age 90 y. Validation studies on older participants are required to confirm this finding.

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同位素稀释空间比在 60 岁以上时下降，可能影响用双标水法估算的总能量消耗1-3, *, ˆ。

双标记水是测量总能量消耗（TEE）的黄金标准。使用该方法进行测量对同位素稀释空间比（DSR）很敏感。如果我们能找出影响同位素稀释空间比的因素，该方法的准确性和精确度可能会得到提高。我们评估了年龄、性别、种族、人体测量、身体成分、同位素周转率和地理海拔高度与 DSR 的潜在关联。我们使用单变量回归分析来探讨连续变量之间的关系，并使用方差分析来检验分类变量与 DSR 之间的关系。随后，我们使用一般线性建模（GLM）和单因素方差分析（One-way ANOVA）同时评估了年龄、性别、种族、无脂肪量（FFM）和脂肪量（FM）与 DSR 的关系。从全球不同种族和生活在不同海拔地区的 5678 个研究数据中得出，平均 DSR 为 1.0364 ± 0.0141（平均值 ± SD）。没有发现任何连续和分类变量对 DSR 产生有意义的生理影响。GLM 分析显示，FFM 和 FM 对 DSR 没有影响（P > 0.33），但在 60 岁及以上的人群中，无论性别如何，DSR 会随着年龄的增长而下降（P < 0.001）。在 60 岁以下的白种人中，DSR 与 FFM 和 FM 无关（P = 0.73），但受到年龄和性别的影响（P < 0.001）。以前对与年龄相关的 TEE 下降的估计可能高估了 90 岁时的 TEE。需要对年龄较大的参与者进行验证研究，以确认这一发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrition 医学-营养学

CiteScore

7.60

自引率

4.80%

发文量

260

审稿时长

39 days

期刊介绍： The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.