Triglyceride-glucose index is associated with all-cause mortality in critically ill patients with alcohol use disorder: a retrospective cohort study.

IF 2.4 3区医学 Q3 ENVIRONMENTAL SCIENCES

Journal of Health, Population, and Nutrition Pub Date : 2024-10-16 DOI:10.1186/s41043-024-00662-9

Yu Pan, Yue-Yue Huang, Lian-Min Ye, Xiao-Hua Zhang, Jing-Ye Pan, Yi-Hua Dong

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引用次数: 0

Abstract

Background: The relationship between Triglyceride-glucose (TyG) index and clinical outcomes in patients with alcohol use disorder (AUD) is unclear. The aim of this study was to evaluate the association between TyG index and all-cause mortality in critically ill patients with AUD.

Methods: We used data from the multi-parameter intelligent monitoring in intensive care IV (MIMIC-IV) database. The patients were equally divided into quartiles. Kaplan-Meier curves were used for survival analysis. The primary endpoint of the study was 28-day mortality, followed by 1-year mortality. We used Cox proportional hazard models to assess the relationship between TyG index and all-cause mortality at different endpoints.

Results: A total of 537 AUD patients were included. Using TyG value as a continuous variable (HR 1.460, 95% CI 1.121-1.903, p = 0.005) and categorical variable (HR 1.447-3.477 from Q2 to Q4, with Q1 as reference), elevated TyG value was significantly associated with increased 28-day mortality. TyG was positively associated with 1-year mortality in AUD patients with an HR of 1.295 (95% CI 1.011-1.659, p = 0.041).

Conclusion: TyG index is positively associated with different clinical outcomes of critically ill AUD patients.

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甘油三酯-葡萄糖指数与酒精使用障碍重症患者的全因死亡率相关：一项回顾性队列研究。

背景：酒精使用障碍（AUD）患者的甘油三酯-葡萄糖（TyG）指数与临床结果之间的关系尚不清楚。本研究旨在评估 AUD 重症患者中 TyG 指数与全因死亡率之间的关系：我们使用了重症监护多参数智能监测 IV（MIMIC-IV）数据库中的数据。患者被平均分为四等分。采用卡普兰-梅耶曲线进行生存分析。研究的主要终点是 28 天死亡率，其次是 1 年死亡率。我们使用 Cox 比例危险模型来评估 TyG 指数与不同终点的全因死亡率之间的关系：结果：共纳入了 537 名 AUD 患者。将 TyG 值作为连续变量（HR 1.460，95% CI 1.121-1.903，p = 0.005）和分类变量（HR 1.447-3.477，从第二季度到第四季度，以第一季度为参考），TyG 值升高与 28 天死亡率增加显著相关。TyG与AUD患者的1年死亡率呈正相关，HR为1.295（95% CI 1.011-1.659，P = 0.041）：TyG指数与AUD重症患者的不同临床结果呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Health, Population, and Nutrition 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Journal of Health, Population and Nutrition brings together research on all aspects of issues related to population, nutrition and health. The journal publishes articles across a broad range of topics including global health, maternal and child health, nutrition, common illnesses and determinants of population health.