Association of oxidative balance score with all-cause mortality among individuals with chronic kidney disease: a cohort study.

IF 2.4 3区医学 Q3 ENVIRONMENTAL SCIENCES

Journal of Health, Population, and Nutrition Pub Date : 2024-10-15 DOI:10.1186/s41043-024-00657-6

Ying Lan, Haoxian Tang, Zhimei Lin, Chao Huang, Lvlin Chen

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Abstract

Background: The Oxidative Balance Score (OBS) is employed for evaluating the body's overall level of oxidative stress. This study aimed to investigate the association between OBS and mortality in individuals with chronic kidney disease (CKD) using a cohort study design.

Methods: We used data from adult participants(≥ 20 years old) in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. CKD is diagnosed based on the Kidney Disease Improving Global Outcomes (KDIGO) guidelines. OBS, which consists of 16 dietary factors and 4 lifestyle factors, categorized into pro-oxidants and antioxidants, with a total score range of 0 to 40 .The OBS was divided into four quartiles (Q1 to Q4), with Q1 (5-12), Q2 (13-18), Q3 (19-24), and Q4 (25-36). We excluded patients with missing data on OBS, CKD, and key covariates.Cox regression analysis were used to examine the relationship between OBS and all-cause mortality in CKD patients. Sensitivity analyses included subgroup analysis and multiple imputation.

Results: We included a total of 3,984 patients with CKD. During an average follow-up period of 103 months, 1,263 cases (31.7%) of all-cause mortality were recorded. In the fully adjusted model, compared to Q1 the hazard ratios (HRs) and 95% confidence intervals (CIs) for Q4 were as follows: OBS 0.80 (0.68, 0.95) (p = 0.012), dietary OBS 0.78 (0.66, 0.92) (p = 0.003), and lifestyle OBS 0.83 (0.70, 0.99) (p = 0.038). Our sensitivity analyses further confirmed the robustness of these results.

Conclusions: Higher OBS was negatively correlated with all-cause mortality risk in American adults with CKD.

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氧化平衡评分与慢性肾病患者全因死亡率的关系：一项队列研究。

背景：氧化平衡评分（OBS）用于评估人体氧化应激的总体水平。本研究采用队列研究设计，旨在调查氧化平衡评分与慢性肾脏病（CKD）患者死亡率之间的关系：我们使用了1999年至2018年美国国家健康与营养调查（NHANES）中成年参与者（≥20岁）的数据。CKD是根据肾病改善全球结果（KDIGO）指南诊断的。OBS由16个饮食因素和4个生活方式因素组成，分为促氧化剂和抗氧化剂，总分范围为0至40 .OBS分为四个四分位数（Q1至Q4），分别为Q1（5-12）、Q2（13-18）、Q3（19-24）和Q4（25-36）。我们排除了OBS、CKD和关键协变量数据缺失的患者。Cox回归分析用于检验OBS与CKD患者全因死亡率之间的关系。敏感性分析包括亚组分析和多重估算：我们共纳入了 3984 名 CKD 患者。在平均 103 个月的随访期间，共记录了 1263 例（31.7%）全因死亡病例。在完全调整模型中，与 Q1 相比，Q4 的危险比（HRs）和 95% 置信区间（CIs）如下：OBS 0.80 (0.68, 0.95) (p = 0.012)，饮食 OBS 0.78 (0.66, 0.92) (p = 0.003)，生活方式 OBS 0.83 (0.70, 0.99) (p = 0.038)。我们的敏感性分析进一步证实了这些结果的稳健性：结论：在患有慢性肾脏病的美国成年人中，较高的 OBS 与全因死亡风险呈负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Health, Population, and Nutrition 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Journal of Health, Population and Nutrition brings together research on all aspects of issues related to population, nutrition and health. The journal publishes articles across a broad range of topics including global health, maternal and child health, nutrition, common illnesses and determinants of population health.