Diagnostic yield of stains for infectious organisms in esophageal or gastroesophageal junction biopsies with esophagitis.

IF 0.6 4区生物学 Q4 CELL BIOLOGY

Journal of Histotechnology Pub Date : 2024-10-14 DOI:10.1080/01478885.2024.2415154

Aaron R Huber, Christa L Whitney-Miller

引用次数: 0

Abstract

Stains frequently performed to exclude infectious etiologies in esophagitis include Grocott methenamine silver (GMS) and periodic acid-Schiff (PAS) as well as immunohistochemistry (IHC) assays for cytomegalovirus (CMV) and herpes simplex virus (HSV). The diagnostic yield of these tests, in this situation, has not been well studied. We retrospectively reviewed 261 esophageal biopsies, which had one or more of the above tests performed. The diagnostic yield for GMS and PAS was 8%, while CMV and HSV immunohistochemistry had a diagnostic yield of 1% and 0%, respectively. Our study suggests that routine use of ancillary labeling techniques in esophagitis biopsies may be of limited utility and have low diagnostic yield.

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食管炎食管或胃食管交界处活检中感染性生物体染色的诊断率。

为排除食管炎的感染性病因而经常进行的染色包括 Grocott methenamine silver (GMS) 和 periodic acid-Schiff (PAS)，以及巨细胞病毒 (CMV) 和单纯疱疹病毒 (HSV) 的免疫组化 (IHC) 检测。在这种情况下，这些检测方法的诊断率还没有得到很好的研究。我们对 261 例食管活检进行了回顾性研究，这些活检进行了上述一种或多种检测。GMS和PAS的诊断率为8%，而CMV和HSV免疫组化的诊断率分别为1%和0%。我们的研究表明，在食管炎活检中常规使用辅助标记技术可能作用有限，诊断率较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Histotechnology 生物-细胞生物学

CiteScore

2.60

自引率

9.10%

发文量

审稿时长

>12 weeks

期刊介绍： The official journal of the National Society for Histotechnology, Journal of Histotechnology, aims to advance the understanding of complex biological systems and improve patient care by applying histotechniques to diagnose, prevent and treat diseases. Journal of Histotechnology is concerned with educating practitioners and researchers from diverse disciplines about the methods used to prepare tissues and cell types, from all species, for microscopic examination. This is especially relevant to Histotechnicians. Journal of Histotechnology welcomes research addressing new, improved, or traditional techniques for tissue and cell preparation. This includes review articles, original articles, technical notes, case studies, advances in technology, and letters to editors. Topics may include, but are not limited to, discussion of clinical, veterinary, and research histopathology.