Subsegmentation of the hippocampus in subgroups of migraine with aura patients: advanced structural neuroimaging study.

IF 7.3 1区 医学 Q1 CLINICAL NEUROLOGY
Igor Petrušić, Mojsije Radović, Marko Daković, Aleksandra Radojičić, Gianluca Coppola
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Abstract

Background: This study investigated for a possible contributing role of hippocampus in the different clinical phenotypic manifestations of migraine aura.

Methods: Herein, patients were categorized as those with pure visual aura (MwAv), those who reported additional somatosensory and dysphasic symptoms (MwAvsd), and healthy controls (HCs). Neuroimaging data obtained using FreeSurfer-based segmentation of hippocampal subfields were compared between HCs and patients with migraine with aura, as well as between HCs and those with MwAv and MwAvsd. The average migraine aura complexity score (MACS) was calculated for each patient to investigate the correlation between hippocampal subfield volume and migraine aura complexity.

Results: Herein, 46 patients with migraine with aura (28 MwAvsd and 18 MwAv) and 31 HCs were included. There were no significant differences in the hippocampal subfields between HCs and patients with migraine with aura. The average MACS negatively correlated with the volumes of the left and right hippocampi, Cornu Ammonis (CA) 1, CA3, CA4, molecular layer, left granule cell layer of the dentate gyrus, hippocampal fissure, and hippocampus-amygdala transition area. The MwAvsd subgroup had significantly smaller whole hippocampal volumes in both hemispheres, as well as in both subicula, compared with the MwAv subgroup and HCs. In addition, the left molecular layer, right CA1, and hippocampal fissures were significantly smaller in the MwAvsd group than in the MwAv subgroup and HCs.

Conclusions: Smaller left and right hippocampal volumes, particularly of the subiculum/CA1 area, may play an important role in the pathophysiology of somatosensory and dysphasic symptoms in migraine with aura.

先兆性偏头痛患者亚群的海马体细分:高级结构神经影像学研究。
研究背景方法:本研究将患者分为纯视觉先兆患者(MwAv)、伴有躯体感觉症状和失语症状的患者(MwAvsd)以及健康对照组(HCs)。研究人员比较了健康对照组与先兆偏头痛患者之间,以及健康对照组与MwAv和MwAvsd患者之间通过基于FreeSurfer的海马亚区分割获得的神经影像数据。计算每位患者的偏头痛先兆复杂性平均得分(MACS),以研究海马亚场体积与偏头痛先兆复杂性之间的相关性:结果:本文纳入了46名先兆偏头痛患者(28名MwAvsd和18名MwAv)和31名HC。HC和先兆偏头痛患者的海马亚区没有明显差异。平均MACS与左右海马、Cornu Ammonis(CA)1、CA3、CA4、分子层、齿状回左颗粒细胞层、海马裂隙和海马-杏仁核过渡区的体积呈负相关。与 MwAv 亚组和 HCs 相比,MwAvsd 亚组两个半球以及两个亚丘的整个海马体积明显较小。此外,MwAvsd 组的左侧分子层、右侧 CA1 和海马裂隙也明显小于 MwAv 亚组和 HCs:结论:左侧和右侧海马体积较小,尤其是钟下/CA1区,可能在有先兆偏头痛患者的躯体感觉症状和失语症状的病理生理学中起重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Headache and Pain
Journal of Headache and Pain 医学-临床神经学
CiteScore
11.80
自引率
13.50%
发文量
143
审稿时长
6-12 weeks
期刊介绍: The Journal of Headache and Pain, a peer-reviewed open-access journal published under the BMC brand, a part of Springer Nature, is dedicated to researchers engaged in all facets of headache and related pain syndromes. It encompasses epidemiology, public health, basic science, translational medicine, clinical trials, and real-world data. With a multidisciplinary approach, The Journal of Headache and Pain addresses headache medicine and related pain syndromes across all medical disciplines. It particularly encourages submissions in clinical, translational, and basic science fields, focusing on pain management, genetics, neurology, and internal medicine. The journal publishes research articles, reviews, letters to the Editor, as well as consensus articles and guidelines, aimed at promoting best practices in managing patients with headaches and related pain.
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