Vitamin B12 is correlated with insulin resistance and metabolism disorder markers in women with recurrent pregnancy loss

IF 1.7 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of gynecology obstetrics and human reproduction Pub Date : 2024-10-18 DOI:10.1016/j.jogoh.2024.102864

Xujing Deng , Dengke Qin , Qiuhong Ding, Liying Peng, Guohua Li, Shihua Bao

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引用次数: 0

Abstract

Objectives

Recurrent pregnancy loss (RPL) seriously affects women's reproductive and mental health, and the incidence has increased in recent years. Insulin resistance (IR) acts as a significant contributing factor to RPL. Studies suggest that vitamin B12, folate intake, and homocysteine are correlated with IR, but the exact nature remains controversial and requires further investigation. In this study, we aimed to assess the levels and correlations between vitamin B12-folate-homocysteine and insulin resistance in RPL patients.

Study design

73 control subjects and 256 RPL patients (144 RPL patients without IR and 112 RPL patients with IR) were included in this observational retrospective cross-sectional study. The differences in vitamin B12, folate, and homocysteine levels between RPL patients with and without IR were analyzed using a Student's t-test. Pearson correlations were utilized to examine the correlation between vitamin B12-folate-homocysteine and glucose and lipid metabolism parameters. Multivariable linear regressions were used to assess the independent correlation of each factor with HOMA-IR.

Results

Compared to the control subjects, RPL patients exhibited lower vitamin B12 (p < 0.001) and folate (p < 0.001), and higher homocysteine (p = 0.001). RPL patients with IR described decreases in vitamin B12 (p = 0.003) and folate (p = 0.028), and increases in homocysteine (p = 0.033) as RPL patients without IR. Vitamin B12 in RPL patients was significantly negatively correlated with homocysteine (r = −0.348, p < 0.001), HOMA-IR (r = −0.214, p < 0.001), BMI (r = −0.160, p = 0.017), TG (r = −0.148, p = 0.039) and CHO (r = −0.149, p = 0.038) and positively correlated with folate (r = 0.217, p < 0.001). In multivariable linear regressions, after adjusting for age, strong correlations were observed between vitamin B12 (β = −0.197, p = 0.010), BMI (β = 0.466, p < 0.001), and HOMA-IR in RPL patients.

Conclusion

Vitamin B12 is significantly correlated with IR in RPL patients. Circulating vitamin B12-folate-homocysteine metabolism could be a window of the pathological process of IR, obesity, and lipid metabolism disorders in RPL patients.

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维生素 B12 与反复妊娠流产妇女的胰岛素抵抗和代谢紊乱指标相关。

目的：反复妊娠流产（RPL）严重影响妇女的生殖健康和心理健康，近年来发病率有所上升。胰岛素抵抗（IR）是导致 RPL 的一个重要因素。研究表明，维生素 B12、叶酸摄入量和同型半胱氨酸与 IR 相关，但其确切性质仍存在争议，需要进一步研究。本研究旨在评估RPL患者体内维生素B12-叶酸-同型半胱氨酸的水平及其与胰岛素抵抗之间的相关性。研究设计：81名对照组受试者和256名RPL患者（144名无IR的RPL患者和112名有IR的RPL患者）被纳入这项观察性回顾横断面研究。采用学生 t 检验分析了有 IR 和无 IR 的 RPL 患者之间维生素 B12、叶酸和同型半胱氨酸水平的差异。利用皮尔逊相关性检验维生素 B12-叶酸-同型半胱氨酸与血糖和血脂代谢参数之间的相关性。多变量线性回归用于评估各因素与 HOMA-IR 的独立相关性：与对照组相比，RPL 患者的维生素 B12（p < 0.001）和叶酸（p < 0.001）含量较低，同型半胱氨酸（p = 0.001）含量较高。与无 IR 的 RPL 患者相比，有 IR 的 RPL 患者维生素 B12（p = 0.003）和叶酸（p = 0.028）降低，同型半胱氨酸（p = 0.033）升高。RPL患者的维生素B12与同型半胱氨酸（r = -0.348，p < 0.001）、HOMA-IR（r = -0.214，p < 0.001）、体重指数（r = -0.160，p = 0.017）、总胆固醇（r = -0.148，p = 0.039）和CHO（r = -0.149，p = 0.038）呈显著负相关，与叶酸（r = 0.217，p < 0.001）呈正相关。在多变量线性回归中，调整年龄后，观察到 RPL 患者的维生素 B12（β = -0.197，p = 0.010）、BMI（β = 0.466，p < 0.001）和 HOMA-IR 之间存在很强的相关性：结论：维生素 B12 与 RPL 患者的 IR 显著相关。循环中的维生素 B12-叶酸-高半胱氨酸代谢可能是 RPL 患者 IR、肥胖和脂质代谢紊乱病理过程的一个窗口。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of gynecology obstetrics and human reproduction Medicine-Obstetrics and Gynecology

CiteScore

3.70

自引率

5.30%

发文量

210

审稿时长

31 days

期刊介绍： Formerly known as Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Journal of Gynecology Obstetrics and Human Reproduction is the official Academic publication of the French College of Obstetricians and Gynecologists (Collège National des Gynécologues et Obstétriciens Français / CNGOF). J Gynecol Obstet Hum Reprod publishes monthly, in English, research papers and techniques in the fields of Gynecology, Obstetrics, Neonatology and Human Reproduction: (guest) editorials, original articles, reviews, updates, technical notes, case reports, letters to the editor and guidelines. Original works include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses.