Intravascular central nervous system T-cell lymphoma in a common dolphin (Delphinus delphis) with cerebral infarction

IF 0.8 4区 农林科学 Q4 PATHOLOGY
Mark E. Wessels , Mariel T.I. ten Doeschate , Richard Fox , Elise Squirrell , Andrew Brownlow
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引用次数: 0

Abstract

Lymphoid and haematopoietic neoplasms are rare in cetaceans. This report describes intravascular lymphoma in an adult common dolphin that presented with neurological signs prior to stranding. Intravascular lymphoma is a rare neoplasm previously recorded in humans, dogs, a cat and a horse. The condition is characterized by intravascular neoplastic lymphocytic proliferation, the sequelae of which are dependent on the organ affected. Key pathological findings in this case included multifocal cerebrocortical malacia secondary to vascular occlusion associated with intravascular neoplastic lymphocytic proliferation. Immunohistochemistry supported a T-cell phenotype similar to that observed in dogs. The neurological presentation was consistent with that seen in other species in which the central nervous system is involved. The aetiology and pathogenesis have not been established in other species and although no further investigations were made in this common dolphin, this report adds to the short list of species affected by this rare neoplasm.
普通海豚(Delphinus delphis)血管内中枢神经系统 T 细胞淋巴瘤并发脑梗塞。
在鲸类动物中,淋巴瘤和造血肿瘤非常罕见。本报告描述了一只成年普通海豚的血管内淋巴瘤,该海豚在搁浅前出现神经症状。血管内淋巴瘤是一种罕见的肿瘤,以前曾在人类、狗、猫和马身上发现过。这种疾病的特征是血管内肿瘤性淋巴细胞增生,其后遗症取决于受影响的器官。该病例的主要病理结果包括继发于血管闭塞和血管内肿瘤性淋巴细胞增生的多灶性大脑皮质畸形。免疫组化结果表明其T细胞表型与在狗身上观察到的相似。神经系统表现与其他涉及中枢神经系统的物种一致。其他物种的病因和发病机理尚未确定,虽然没有对该普通海豚进行进一步研究,但本报告为受这种罕见肿瘤影响的物种增加了一个简短的名单。
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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
208
审稿时长
50 days
期刊介绍: The Journal of Comparative Pathology is an International, English language, peer-reviewed journal which publishes full length articles, short papers and review articles of high scientific quality on all aspects of the pathology of the diseases of domesticated and other vertebrate animals. Articles on human diseases are also included if they present features of special interest when viewed against the general background of vertebrate pathology.
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