The Emerging Role of GLP-1 Agonists in Burn Care: What Do We Know?

IF 1.5 4区医学 Q3 CRITICAL CARE MEDICINE

Journal of Burn Care & Research Pub Date : 2025-03-04 DOI:10.1093/jbcr/irae189

Artur Manasyan, Brigette Cannata, Erin Ross, Sasha Lasky, Eloise W Stanton, Nicolas Malkoff, Zachary Collier, Maxwell B Johnson, Timothy Justin Gillenwater

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引用次数: 0

Abstract

Glucagon-like peptide-1 (GLP-1) agonists mimic the action of GLP-1, a hormone that regulates blood glucose levels via stimulation of insulin release and inhibition of glucagon secretion. After the burn, the current literature suggests that the use of GLP-1 agonists results in less insulin dependence with similar glucose control and hypoglycemic events to patients receiving a basal-bolus insulin regimen. Glucagon-like peptide-1 agonists may also promote wound healing through various mechanisms including angiogenesis and improved keratinocyte migration. Despite the potential benefits, GLP-1 agonists reduce gastrointestinal motility which impacts their widespread adoption in burn care. This dysmotility can result in inadequate nutrition delivery, unintentional weight loss, and is a potential aspiration risk. The net impact of these medications on patients with burns is unclear. Given their potential to demonstrate the safety, efficacy, and optimal dosing of various GLP-1 agonists in acute burn management.

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GLP-1 激动剂在烧伤护理中的新作用：我们知道什么？

胰高血糖素样肽-1（GLP-1）激动剂可模拟 GLP-1 的作用，GLP-1 是一种通过刺激胰岛素释放和抑制胰高血糖素分泌来调节血糖水平的激素。目前的文献表明，胰岛素燃烧后，使用 GLP-1 激动剂可减少对胰岛素的依赖，血糖控制和低血糖事件与接受基础胰岛素治疗的患者相似。GLP-1 激动剂还可通过各种机制促进伤口愈合，包括血管生成和改善角质细胞迁移。尽管 GLP-1 激动剂具有潜在的益处，但它会降低胃肠道的蠕动能力，从而影响其在烧伤护理中的广泛应用。这种运动障碍会导致营养输送不足、体重意外减轻，并有吸入的潜在风险。这些药物对烧伤患者的净影响尚不清楚。鉴于这些研究有可能证明各种 GLP-1 激动剂在急性烧伤治疗中的安全性、有效性和最佳剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Burn Care & Research 医学-外科

CiteScore

2.60

自引率

21.40%

发文量

535

审稿时长

4-8 weeks

期刊介绍： Journal of Burn Care & Research provides the latest information on advances in burn prevention, research, education, delivery of acute care, and research to all members of the burn care team. As the official publication of the American Burn Association, this is the only U.S. journal devoted exclusively to the treatment and research of patients with burns. Original, peer-reviewed articles present the latest information on surgical procedures, acute care, reconstruction, burn prevention, and research and education. Other topics include physical therapy/occupational therapy, nutrition, current events in the evolving healthcare debate, and reports on the newest computer software for diagnostics and treatment. The Journal serves all burn care specialists, from physicians, nurses, and physical and occupational therapists to psychologists, counselors, and researchers.