Three-dimensional visualization of uterine nerve fiber distribution using fluorescence micro-optical sectioning tomography (fMOST): A pilot study.

IF 1.8 3区医学 Q2 ANATOMY & MORPHOLOGY

Journal of Anatomy Pub Date : 2024-10-22 DOI:10.1111/joa.14157

Yonglan Deng, Yirong Zhang, Fei Gao, Yifeng Lin, Pei Li, Yanjuan Qiu, Lin Yang

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Abstract

Study objective: This study aimed to observe and quantitatively analyze the morphology and distribution of uterine nerve fibers using fluorescence micro-optical sectioning tomography (fMOST). The goal was to provide an accurate morphological reference for pathological evaluations of uterine nerves.

Measurements and main results: Using fMOST technique, we observed and analyzed the distribution of nerve fibers within the uterus. Our findings revealed a radial dispersion of nerve fibers radiating from myometrium to endometrium. The cervix uteri region exhibited a high density of nerve fibers, displaying terminations in a flower spray pattern. In contrast, nerve fibers in corpus uteri were comparatively sparse. However, we identified a unique "vine-like" pattern of a single nerve fiber extending from myometrium to endometrial layer in areas with concentrated nerves.

Conclusions: The fMOST technique is able to effectively elucidate the morphology and distribution of uterine nerve fibers. This method enables three-dimensional visualization of nerves in myometrium and offers a novel approach to observe the pathological changes in uterine nerves.

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利用荧光显微光学切片断层成像技术（fMOST）对子宫神经纤维分布进行三维可视化：试点研究。

研究目的本研究旨在利用荧光显微光学切片断层成像技术（fMOST）观察和定量分析子宫神经纤维的形态和分布。目的是为子宫神经的病理评估提供准确的形态学参考：利用荧光显微光学切片断层成像技术，我们观察并分析了子宫内神经纤维的分布情况。我们的研究结果显示，神经纤维呈放射状分布，从子宫肌层向子宫内膜辐射。子宫颈区的神经纤维密度较高，末端呈花朵状。相比之下，子宫体部的神经纤维相对稀疏。然而，在神经集中的区域，我们发现了单根神经纤维从子宫肌层延伸至子宫内膜层的独特 "藤蔓状 "模式：结论：fMOST 技术能有效阐明子宫神经纤维的形态和分布。该方法可实现子宫神经的三维可视化，为观察子宫神经的病理变化提供了一种新方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Anatomy 医学-解剖学与形态学

CiteScore

4.80

自引率

8.30%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Journal of Anatomy is an international peer-reviewed journal sponsored by the Anatomical Society. The journal publishes original papers, invited review articles and book reviews. Its main focus is to understand anatomy through an analysis of structure, function, development and evolution. Priority will be given to studies of that clearly articulate their relevance to the anatomical community. Focal areas include: experimental studies, contributions based on molecular and cell biology and on the application of modern imaging techniques and papers with novel methods or synthetic perspective on an anatomical system. Studies that are essentially descriptive anatomy are appropriate only if they communicate clearly a broader functional or evolutionary significance. You must clearly state the broader implications of your work in the abstract. We particularly welcome submissions in the following areas: Cell biology and tissue architecture Comparative functional morphology Developmental biology Evolutionary developmental biology Evolutionary morphology Functional human anatomy Integrative vertebrate paleontology Methodological innovations in anatomical research Musculoskeletal system Neuroanatomy and neurodegeneration Significant advances in anatomical education.