Immune checkpoint inhibitors in cancer patients from the perspective of pharmaceutical care: a scoping review.

IF 1.5 Q3 PHARMACOLOGY & PHARMACY
Giselle Amorim Lira, Júlia de Andrade Brandão, Leticia Anderson, Ênio José Bassi
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引用次数: 0

Abstract

Background: Cancer treatment has become a significant health challenge, with notable changes in recent years due to increasing knowledge of cancer biology. The use of immune checkpoint inhibitors (ICIs) has shown promising results, but they can induce adverse events (AEs), resulting in serious consequences for patients. Pharmaceutical care aims to prevent, identify, and address issues related to medications, such as AEs.

Aim: The objective of this scoping review was to assess the contribution of pharmacists to the intervention and care of cancer patients undergoing treatment with ICIs.

Methods: The PubMed, Scopus, Embase, and Web of Science databases were searched for studies on the treatment of cancer patients treated with ICIs in which pharmacists participated. No time frame or language restriction was applied. Article screening was performed independently by two authors, with any discrepancies resolved by a third author. The studies were analyzed and included in this review following the inclusion and exclusion criteria.

Results: Nine studies fulfilled the inclusion criteria. Pharmaceutical care encompasses a variety of interventions, including providing guidance to patients and to the multidisciplinary team, monitoring and managing AEs, conducting pharmaceutical consultations, and recommending over-the-counter medications and laboratory tests, among other actions. Pharmaceutical recommendations led to better outcomes regarding AEs.

Conclusions: Pharmaceutical care has a positive impact on oncological immunotherapy with ICIs, contributing to both health institutions through cost reduction and, most importantly, patients by improving treatment outcomes and enhancing the quality of life.

从药物治疗的角度看癌症患者使用免疫检查点抑制剂:范围界定综述。
背景:癌症治疗已成为一项重大的健康挑战,近年来,由于对癌症生物学的认识不断加深,癌症治疗发生了显著变化。免疫检查点抑制剂(ICIs)的使用已显示出良好的效果,但它们可能诱发不良事件(AEs),给患者造成严重后果。药学护理旨在预防、识别和解决与药物有关的问题,如 AEs。目的:本范围综述旨在评估药剂师对接受 ICIs 治疗的癌症患者的干预和护理所做的贡献:方法:在 PubMed、Scopus、Embase 和 Web of Science 数据库中搜索药剂师参与的有关癌症患者接受 ICIs 治疗的研究。没有时间或语言限制。文章筛选由两位作者独立完成,任何不一致之处由第三位作者解决。按照纳入和排除标准对研究进行分析并纳入本综述:九项研究符合纳入标准。药物护理包含多种干预措施,包括为患者和多学科团队提供指导、监测和管理AE、进行药物咨询、推荐非处方药和实验室检查等。药物建议可改善AEs的治疗效果:结论:药物治疗对使用 ICIs 的肿瘤免疫疗法有积极影响,可通过降低成本为医疗机构做出贡献,最重要的是,可通过改善治疗效果和提高生活质量为患者做出贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.90
自引率
5.60%
发文量
146
期刊介绍: The International Journal of Pharmacy Practice (IJPP) is a Medline-indexed, peer reviewed, international journal. It is one of the leading journals publishing health services research in the context of pharmacy, pharmaceutical care, medicines and medicines management. Regular sections in the journal include, editorials, literature reviews, original research, personal opinion and short communications. Topics covered include: medicines utilisation, medicine management, medicines distribution, supply and administration, pharmaceutical services, professional and patient/lay perspectives, public health (including, e.g. health promotion, needs assessment, health protection) evidence based practice, pharmacy education. Methods include both evaluative and exploratory work including, randomised controlled trials, surveys, epidemiological approaches, case studies, observational studies, and qualitative methods such as interviews and focus groups. Application of methods drawn from other disciplines e.g. psychology, health economics, morbidity are especially welcome as are developments of new methodologies.
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