Temporal trajectories of long-COVID symptoms in adults with 22 months follow-up in a prospective cohort study in Norway

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2024-10-15 DOI:10.1016/j.ijid.2024.107263

Merete Ellingjord-Dale , Anders Benteson Nygaard , Nathalie C. Støer , Ragnhild Bø , Nils Inge Landrø , Sonja Hjellegjerde Brunvoll , Mette Istre , Karl Trygve Kalleberg , John Arne Dahl , Linda Geng , Kostas Tsilidis , Elio Riboli , Giske Ursin , Arne Søraas

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引用次数: 0

Abstract

Objectives

There is a lack of large studies on long-COVID symptoms with symptoms measurements before the onset of COVID-19. Therefore, long-COVID is still poorly defined.

Methods

The Norwegian COVID-19 Cohort Study is a population-based, open cohort of adult participants (aged 18-96 years) from Norway. From March 27, 2020, participants were recruited through social media, invitations, and nationwide media coverage. Fourteen somatic and cognitive symptoms were assessed at baseline and four follow-ups for up to 22 months. SARS-CoV-2 test status was obtained from a mandatory national registry or from self-report.

Results

After follow-up, 15 737 participants had a SARS-CoV-2-positive test, 67 305 had a negative test, and 37 563 were still untested. Persistent symptoms reported more frequently by positive compared with negative participants one month after infection, were memory problems (3-6 months: adjusted odds ratio (aOR) = 6.8, CI = 5.7-8.1; >18 months: aOR = 9.4, CI = 4.1-22), and concentration problems (3-6 months: aOR = 4.1, CI = 3.5-4.7; >18 months: aOR = 4.4, CI = 2.0-9.7) as well fatigue, dyspnea, anosmia and dysgeusia.

Conclusions

COVID-19 was associated with cognitive symptoms, anosmia, dysgeusia, dyspnea, and fatigue as well as worsening of overall health up to 22 months after a SARS-CoV-2 test, even when correcting for symptoms before the onset of COVID-19.

查看原文本刊更多论文

挪威一项为期 22 个月的前瞻性队列研究显示，成人长期 COVID 症状的时间轨迹。

背景：目前还缺乏关于长COVID症状的大型研究，这些症状是在COVID-19发病前测量的。因此，长期 COVID 的定义仍不明确：挪威 COVID-19 队列研究是一项基于人口的开放式队列研究，研究对象为挪威的成年参与者（18-96 岁）。自 2020 年 3 月 27 日起，通过社交媒体、邀请函和全国性媒体报道招募参与者。在基线和长达 22 个月的四次随访中对 14 种躯体和认知症状进行了评估。SARS-CoV-2检测情况通过强制性国家登记册或自我报告获得：随访后，15 737 名参与者的 SARS-CoV-2 检测结果为阳性，67 305 名参与者的检测结果为阴性，37 563 名参与者的检测结果为阳性，37 563 名参与者的检测结果为阴性。与阴性参与者相比，阳性参与者在感染一个月后更常报告的持续症状是记忆问题（3-6 个月：调整后的几率比（aOR）= 6.8，CI = 5.7-8.1；>18 个月：调整后的几率比（aOR）= 6.8，CI = 5.7-8.1）。1；>18 个月：aOR = 9.4，CI = 4.1-22）、注意力不集中（3-6 个月：aOR = 4.1，CI = 3.5-4.7；>18 个月：aOR = 4.4，CI = 2.0-9.7）以及疲劳、呼吸困难、嗅觉障碍和味觉障碍：COVID-19与认知症状、嗅觉障碍、味觉障碍、呼吸困难和疲劳以及总体健康状况的恶化有关，最长可达SARS-CoV-2检测后22个月，即使对COVID-19发病前的症状进行校正也是如此。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.