Delayed Trastuzumab-induced Cardiotoxicity Leading to Severe Left Ventricular Dysfunction.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-06-15 Epub Date: 2024-10-18 DOI:10.2169/internalmedicine.4144-24

Ikuo Misumi, Reiki Nishimura, Shota Nakamura, Koji Sato, Miwa Dekita, Hiroki Usuku, Kenichi Tsujita

引用次数: 0

Abstract

An 81-year-old woman presented to our hospital with dyspnea. She had been treated with trastuzumab for nine years. Chest radiography revealed pleural effusion. Transthoracic echocardiography revealed dyskinesis of the interventricular septum (IVS). Cardiac magnetic resonance imaging revealed increased native T1 values at the IVS and apex, indicating myocardial edema or fibrosis in these areas. A transthoracic echocardiogram after half a year revealed an increase in left ventricular ejection fraction from 25% to 48%. Serial transthoracic echocardiography and cardiac magnetic resonance imaging were useful for evaluating the cardiac structure and function in the present case of delayed trastuzumab-induced myocardial injury.

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曲妥珠单抗诱发的迟发性心脏毒性导致严重左心室功能障碍

一名 81 岁的妇女因呼吸困难来到我院就诊。她接受曲妥珠单抗治疗已有九年。胸片检查发现胸腔积液。经胸超声心动图显示室间隔（IVS）运动障碍。心脏磁共振成像显示室间隔和心尖的原生 T1 值增高，表明这些区域存在心肌水肿或纤维化。半年后，经胸超声心动图显示 LVEF 从 25% 增至 48%。在本例曲妥珠单抗诱发的延迟性心肌损伤中，连续经胸超声心动图和心脏磁共振成像有助于评估心脏结构和功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.