Limb salvage using radical combined hyperthermia and radiotherapy for myxofibrosarcoma of the lower leg in an elderly patient.

IF 0.5 Q4 ONCOLOGY
International Cancer Conference Journal Pub Date : 2024-08-30 eCollection Date: 2024-10-01 DOI:10.1007/s13691-024-00719-w
Katsuhiro Esaki, Tomoya Matsunobu, Satoshi Nomoto, Yumi Shimohata, Akira Maekawa, Masato Yoshimoto
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Abstract

Soft tissue sarcomas account for only 1.5% of malignant tumors in adults and are therefore challenging to treat. We present a case of myxofibrosarcoma of the lower leg in an 88-year-old woman who successfully responded to combined hyperthermia and radiotherapy. We proposed a below-knee amputation because of the spread of the lesion, but the patient opted for hyperthermia with radiotherapy. One and a half years later, the tumor partially regrew, and the regrown mass was resected with an R0 margin. Unfortunately, the patient developed a surgical site infection immediately after the resection, and a skin ulcer formed. It took about 2 years for conservative treatment to result in complete ulcer epithelization. The patient has been ambulant, and has not experienced any symptoms of local recurrence or metastasis in the two and a half years since the surgery. Although adverse events related to combined hyperthermia and radiotherapy, such as delayed wound healing, should be considered, it could be an option for the treatment of localized soft-tissue sarcoma, especially in elderly patients.

使用根治性联合热疗和放疗挽救一名老年小腿肌纤维肉瘤患者的肢体。
软组织肉瘤仅占成人恶性肿瘤的 1.5%,因此治疗难度很大。我们介绍了一例小腿肌纤维肉瘤病例,患者是一名 88 岁的女性,对热疗和放疗联合疗法反应良好。由于病灶扩散,我们建议进行膝下截肢手术,但患者选择了热疗加放疗。一年半后,肿瘤部分复发,以R0边缘切除了复发的肿块。不幸的是,患者在切除术后立即出现了手术部位感染,并形成了皮肤溃疡。经过大约两年的保守治疗,溃疡才完全上皮化。手术后的两年半时间里,患者一直行动自如,没有出现任何局部复发或转移症状。虽然应考虑到与热疗和放疗联合治疗相关的不良反应,如伤口愈合延迟等,但这不失为治疗局部软组织肉瘤的一种选择,尤其是对老年患者而言。
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来源期刊
自引率
14.30%
发文量
57
期刊介绍: This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)
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