A case of pagetoid spread of urothelial carcinoma with notable reduction achieved through enfortumab vedotin, resulting in complete surgical resection.

IF 0.5 Q4 ONCOLOGY
International Cancer Conference Journal Pub Date : 2024-08-31 eCollection Date: 2024-10-01 DOI:10.1007/s13691-024-00720-3
Kenichi Tokuoka, Katsuki Muramoto, Keigo Sakanaka, Kentaro Yoshihara, Shutaro Yamamoto, Yu Imai, Kosuke Iwatani, Kojiro Tashiro, Masaya Murakami, Tohru Harada, Takuya Hayashimoto, Miyaka Umemori, Takahiro Kimura, Tatsuya Shimomura, Fumihiko Urabe
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引用次数: 0

Abstract

Secondary extramammary Paget's disease is a rare condition associated with the contiguous extension of tumor cells from the underlying adnexal structures, genitourinary, or gastrointestinal tracts. We report the case of an 80-year-old female with a 7-year history of urothelial carcinoma who presented with erythema of the labia majora. The diagnosis was pagetoid spread of urothelial carcinoma. The patient declined surgical resection of the lesion. She underwent nine cycles of first-line platinum-based chemotherapy and received one course of pembrolizumab for metastatic urothelial carcinoma. As the lesion progressively enlarged, third-line therapy with enfortumab vedotin was initiated, which resulted in significant tumor reduction. This allowed for a successful surgical complete resection of the tumor. Enfortumab vedotin was highly effective and demonstrated dramatic efficacy for controlling extramammary Paget's disease secondary to urothelial carcinoma.

一例通过恩福单抗维多汀显著缩小病灶,并最终完成手术切除的尿路上皮癌的片状扩散病例。
继发性乳腺外帕吉特氏病是一种罕见的疾病,与肿瘤细胞从下层附件结构、泌尿生殖道或胃肠道毗连延伸有关。我们报告了一例 80 岁女性的病例,她有 7 年的尿路上皮癌病史,并伴有大阴唇红斑。诊断结果为尿路上皮癌的片状扩散。患者拒绝手术切除病灶。她接受了九个周期的一线铂类化疗,并接受了一个疗程的pembrolizumab治疗转移性尿路上皮癌。随着病灶逐渐扩大,她开始接受恩福单抗维多汀的三线治疗,结果肿瘤明显缩小。手术成功地完全切除了肿瘤。恩福单抗维多汀在控制继发于尿路上皮癌的乳腺外帕吉特氏病方面效果显著。
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来源期刊
自引率
14.30%
发文量
57
期刊介绍: This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)
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