Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis.

IF 4.8 3区医学 Q2 CELL BIOLOGY

Inflammation Research Pub Date : 2024-10-14 DOI:10.1007/s00011-024-01959-5

Wei Li, Xiaoning Wang, Houze Diao, Yuting Yang, Liyi Ding, Wenru Huan, Yaozhi Chen, Weiwei Cui

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引用次数: 0

Abstract

Importance: Studies have reported an association among systemic immune inflammation index (SII), all-cause and cause-specific mortality, but the results are inconsistent.

Objective: To comprehensively explore the association between Systemic Immune Inflammation (SII) and the risk of all-cause mortality, cardiovascular disease (CVD), and cancer mortality.

Evidence review: A meta-analysis was conducted by reviewing existing literature. The search encompassed prominent databases including PubMed, Embase, Cochrane, and the Web of Science, with the cutoff date set at March 1, 2024. Furthermore, subgroup analyses and dose-response assessments were undertaken to provide a nuanced exploration of mortality risk factors.

Findings: A total of 33 articles were included (427,819 participants). In the study, SII was associated with an increased risk of all-cause mortality (HR = 1.45, 95%CI [1.36,1.54], P < 0.05). SII increased the risk of CVD mortality (HR = 1.44, 95%CI [1.29,1.60], P < 0.05). The Linear independence shows that for every 100 units increase in SII, the risk of all-cause and CVD death increases by 5% and 6%. SII was not associated with a statistically significant risk of cancer death (HR = 1.09, 95%CI [0.96,1.23], P < 0.05).

Conclusions and relevance: Meta-analysis showed that SII was associated with all-cause mortality and CVD mortality. More data and basic research are needed to confirm the association.

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全身免疫炎症指数与全因和特定原因死亡率的关系：一项荟萃分析。

重要性：有研究报告称，全身免疫炎症指数（SII）与全因和特定病因死亡率之间存在关联，但结果并不一致：全面探讨全身免疫炎症（SII）与全因死亡率、心血管疾病（CVD）和癌症死亡率风险之间的关联：证据回顾：通过回顾现有文献进行了一项荟萃分析。检索范围包括PubMed、Embase、Cochrane和Web of Science等著名数据库，截止日期为2024年3月1日。此外，还进行了亚组分析和剂量反应评估，以深入探讨死亡风险因素：共纳入 33 篇文章（427 819 名参与者）。在研究中，SII 与全因死亡风险增加有关（HR = 1.45，95%CI [1.36,1.54]，P 结论和相关性：Meta 分析表明，SII 与全因死亡率和心血管疾病死亡率相关。需要更多的数据和基础研究来证实这种关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammation Research 医学-免疫学

CiteScore

9.90

自引率

1.50%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Inflammation Research (IR) publishes peer-reviewed papers on all aspects of inflammation and related fields including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical investigations and the effect of drugs. Related fields are broadly defined and include for instance, allergy and asthma, shock, pain, joint damage, skin disease as well as clinical trials of relevant drugs.