Myosteatosis and sarcopenia are linked to autonomous cortisol secretion in patients with aldosterone-producing adenomas.

IF 4.3 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Hypertension Research Pub Date : 2024-10-14 DOI:10.1038/s41440-024-01933-y

Bo-Ching Lee, Yu-Ling Chang, Po-Ting Chen, Li-Wen Liu, Kao-Lang Liu, Chin-Chen Chang, Vin-Cent Wu, Yen-Hung Lin

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引用次数: 0

Abstract

Patients with adrenal aldosterone-producing adenomas (APA) face elevated cardiovascular risks, especially when cortisol is co-secreted, yet the impact on muscle health remains unclear. Myosteatosis, characterized by fatty infiltration into muscles, is linked to cardiometabolic diseases and decreased survival. We aimed to investigate the association between autonomous cortisol secretion (ACS) in APA and muscle quantity and quality. In this study, we analyzed data from 228 APA patients undergoing laparoscopic adrenalectomy between 2009 and 2024, assessing muscle composition via computed tomography. Intermuscular adipose tissue (IMAT), skeletal muscle area and density, visceral and subcutaneous adipose tissue area at L3 were measured. Comparisons were made between ACS and non-ACS groups. We found that among 228 patients, 76 (33.3%) had ACS. Those with ACS exhibited significantly higher IMAT area (P = 0.042) and lower skeletal muscle area (P = 0.002) and density (P < 0.001). Multivariable regression confirmed ACS positively associated with IMAT area and negatively associated with skeletal muscle area and density. At 1-year follow-up, ACS patients (n = 15) experienced decreased IMAT area (P = 0.001) and increased skeletal muscle area (P = 0.031) post-adrenalectomy, while those without ACS (n = 29) showed no IMAT change but increased visceral (P < 0.001) and subcutaneous (P = 0.008) adipose tissue area. In summary, myosteatosis and sarcopenia are linked to ACS in APA patients, and these parameters improve following adrenalectomy.

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醛固酮腺瘤患者的肌骨质疏松症和肌肉疏松症与自主皮质醇分泌有关。

肾上腺醛固酮分泌性腺瘤（APA）患者面临着心血管风险升高的问题，尤其是在同时分泌皮质醇的情况下，但其对肌肉健康的影响仍不清楚。肌肉骨质疏松症的特征是肌肉中的脂肪浸润，它与心血管代谢疾病和存活率下降有关。我们旨在研究 APA 中皮质醇自主分泌（ACS）与肌肉数量和质量之间的关系。在这项研究中，我们分析了 228 名在 2009 年至 2024 年间接受腹腔镜肾上腺切除术的 APA 患者的数据，并通过计算机断层扫描评估了肌肉成分。我们测量了肌肉间脂肪组织（IMAT）、骨骼肌面积和密度、内脏和皮下脂肪组织在 L3 的面积。对 ACS 组和非 ACS 组进行了比较。我们发现，在 228 名患者中，有 76 人（33.3%）患有 ACS。患有 ACS 的患者的 IMAT 面积明显较高（P = 0.042），骨骼肌面积（P = 0.002）和密度（P = 0.003）明显较低（P = 0.004）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hypertension Research 医学-外周血管病

CiteScore

7.40

自引率

16.70%

发文量

249

审稿时长

3-8 weeks

期刊介绍： Hypertension Research is the official publication of the Japanese Society of Hypertension. The journal publishes papers reporting original clinical and experimental research that contribute to the advancement of knowledge in the field of hypertension and related cardiovascular diseases. The journal publishes Review Articles, Articles, Correspondence and Comments.