Xiaolan Ouyang, Xixiang Tang, Long Peng, Hongxing Wu, Jiafu Wang, Zhuoshan Huang, Bingyuan Wu, Yue Li, Yan Lu, Xiaodong Zhuang, Yesheng Ling, Suhua Li
{"title":"Remnant cholesterol and new-onset atrial fibrillation: The Atherosclerosis Risk in Communities study.","authors":"Xiaolan Ouyang, Xixiang Tang, Long Peng, Hongxing Wu, Jiafu Wang, Zhuoshan Huang, Bingyuan Wu, Yue Li, Yan Lu, Xiaodong Zhuang, Yesheng Ling, Suhua Li","doi":"10.1016/j.hrthm.2024.10.030","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The relationship between remnant cholesterol (RC) and atrial fibrillation (AF) remains unclear.</p><p><strong>Objective: </strong>The purpose of this study was to comprehensively explore the association between RC characteristics and new-onset AF.</p><p><strong>Methods: </strong>Data from 5 follow-up visits of the ARIC (Atherosclerosis Risk in Communities) study were analyzed. RC were multidimensionally evaluated in 4 characteristics: baseline level, variability, cumulative exposure, and trajectory. Baseline RC was obtained from the initial visit (V1), and new-onset AF was monitored in V2 to V5 (cohort 1, n = 14,450). RC variability, cumulative RC, and RC trajectory were calculated by RC values gathered from V1 to V3, and new-onset AF was monitored in V4 and V5 (cohort 2, n = 11,012). Participants were divided into 4 groups based on quartiles or trajectories. Cox proportional hazards analyses were used to investigate the relationship between RC characteristics and AF.</p><p><strong>Results: </strong>Following median follow-up of 22.39 years in cohort 1 and 16.71 years in cohort 2, a total of 1993 AF events in cohort 1 and 1571 in cohort 2 were identified. Participants with the highest quartile exhibited an elevated risk of new-onset AF, with the multivariable-adjusted hazard ratios of 1.16 (P = .039) for baseline RC and 1.30 (P < .001) for RC variability. Although the highest quartile of cumulative RC (P = .241) and the high-increasing trajectory (P = .210) did not demonstrate a statistically significant association with AF occurrence, they indicate a trend toward heightened risk.</p><p><strong>Conclusion: </strong>Our findings reveal that higher levels of RC, particularly at baseline and in variability, are associated with an increased risk of AF.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":null,"pages":null},"PeriodicalIF":8.3000,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Materials & Interfaces","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.hrthm.2024.10.030","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The relationship between remnant cholesterol (RC) and atrial fibrillation (AF) remains unclear.
Objective: The purpose of this study was to comprehensively explore the association between RC characteristics and new-onset AF.
Methods: Data from 5 follow-up visits of the ARIC (Atherosclerosis Risk in Communities) study were analyzed. RC were multidimensionally evaluated in 4 characteristics: baseline level, variability, cumulative exposure, and trajectory. Baseline RC was obtained from the initial visit (V1), and new-onset AF was monitored in V2 to V5 (cohort 1, n = 14,450). RC variability, cumulative RC, and RC trajectory were calculated by RC values gathered from V1 to V3, and new-onset AF was monitored in V4 and V5 (cohort 2, n = 11,012). Participants were divided into 4 groups based on quartiles or trajectories. Cox proportional hazards analyses were used to investigate the relationship between RC characteristics and AF.
Results: Following median follow-up of 22.39 years in cohort 1 and 16.71 years in cohort 2, a total of 1993 AF events in cohort 1 and 1571 in cohort 2 were identified. Participants with the highest quartile exhibited an elevated risk of new-onset AF, with the multivariable-adjusted hazard ratios of 1.16 (P = .039) for baseline RC and 1.30 (P < .001) for RC variability. Although the highest quartile of cumulative RC (P = .241) and the high-increasing trajectory (P = .210) did not demonstrate a statistically significant association with AF occurrence, they indicate a trend toward heightened risk.
Conclusion: Our findings reveal that higher levels of RC, particularly at baseline and in variability, are associated with an increased risk of AF.
期刊介绍：
ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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