Development and application of a physiologically-based pharmacokinetic model for ractopamine in goats.

IF 2.6 2区农林科学 Q1 VETERINARY SCIENCES

Frontiers in Veterinary Science Pub Date : 2024-10-02 eCollection Date: 2024-01-01 DOI:10.3389/fvets.2024.1399043

Jing Ai, Yunfeng Gao, Fan Yang, Zhen Zhao, Jin Dong, Jing Wang, Shiyi Fu, Ying Ma, Xu Gu

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引用次数: 0

Abstract

Physiologically Based Pharmacokinetic (PBPK) models can provide forecasts of the drug residues within the organism. Ractopamine (RAC) is a typical β-agonist. In this study, we developed a PBPK model for RAC in goats. The goal was to predict the distribution of the drug after multiple oral administrations. The preliminary PBPK model for RAC in goats performed well in predicting the drug's distribution in most tissues. In our sensitivity analysis, we found that the parameter of Qclu (Blood Flow Volume through Lungs) had the greatest impact on the RAC concentrations in plasma, liver, and kidney and was the most sensitive parameter. Furthermore, our study aimed to assess the withdrawal time (WT) of RAC in different tissues after RAC long-term exposure in goats. We found that the WT of RAC in the kidney was the longest, lasting for 13 days. Overall, the insights gained from this study have important implications for optimizing drug administration in goats and ensuring appropriate withdrawal times to prevent any potential risks.

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开发和应用基于生理学的莱克多巴胺山羊药代动力学模型。

基于生理学的药物代谢动力学（PBPK）模型可以预测药物在机体内的残留量。莱克多巴胺（RAC）是一种典型的β-兴奋剂。在这项研究中，我们为山羊体内的 RAC 建立了一个 PBPK 模型。目的是预测该药物在多次口服后的分布情况。初步建立的山羊 RAC PBPK 模型在预测药物在大多数组织中的分布方面表现良好。在敏感性分析中，我们发现 Qclu（通过肺部的血流量）参数对血浆、肝脏和肾脏中的 RAC 浓度影响最大，是最敏感的参数。此外，我们的研究还旨在评估山羊长期接触 RAC 后不同组织中 RAC 的撤出时间（WT）。我们发现，肾脏中 RAC 的 WT 时间最长，持续了 13 天。总之，本研究获得的见解对优化山羊用药和确保适当的停药时间以防止任何潜在风险具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Veterinary Science Veterinary-General Veterinary

CiteScore

4.80

自引率

9.40%

发文量

1870

审稿时长

14 weeks

期刊介绍： Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy. Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field. Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.