Glucagon and glucagon-like peptide-1 dual agonist therapy: A possible future towards fatty kidney disease

IF 4.4 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Mehmet Kanbay, Sidar Copur, Mustafa Guldan, Lasin Ozbek, Francesca Mallamaci, Carmine Zoccali
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Abstract

Background

Obesity is a growing epidemic affecting approximately 40% of the adult population in developed countries with major health consequences and comorbidities, including diabetes mellitus and insulin resistance, metabolically associated fatty liver disease, atherosclerotic cardiovascular and cerebrovascular diseases and chronic kidney disease. Pharmacotherapies targeting significant weight reduction may have beneficial effects on such comorbidities, though such therapeutic options are highly limited. In this narrative review, we aim to evaluate current knowledge regarding dual agonist therapies and potential implications for managing fatty kidney and chronic kidney disease.

Results and Conclusion

Glucagon-like peptide-1 agonists and sodium-glucose cotransporter-2 inhibitors are two novel classes of glucose-lowering medications with potential implications and beneficiary effects on renal outcomes, including estimated glomerular filtration rate, albuminuria and chronic kidney disease progression. Recently, dual agonist therapies targeting glucagon-like peptide-1 and glucagon receptors, namely survodutide and cotadutide, have been evaluated in managing metabolically associated fatty liver disease, a well-established example of visceral obesity. Fatty kidney is another novel concept implicated in the pathophysiology of chronic kidney disease among patients with visceral obesity.

胰高血糖素和胰高血糖素样肽-1 双激动剂疗法:脂肪性肾病的可能未来。
背景:肥胖症是一种日益严重的流行病,在发达国家约有 40% 的成年人患有肥胖症,并对健康造成严重影响和并发症,包括糖尿病和胰岛素抵抗、代谢性脂肪肝、动脉粥样硬化性心脑血管疾病和慢性肾病。以显著减轻体重为目标的药物疗法可能会对这些并发症产生有益的影响,尽管此类治疗选择非常有限。在这篇叙述性综述中,我们旨在评估目前有关双重激动剂疗法的知识以及对控制脂肪肾和慢性肾病的潜在影响:胰高血糖素样肽-1 激动剂和钠-葡萄糖共转运体-2 抑制剂是两类新型降糖药物,对肾脏预后(包括估计肾小球滤过率、白蛋白尿和慢性肾脏病进展)具有潜在影响和受益效应。最近,针对胰高血糖素样肽-1 和胰高血糖素受体的双激动剂疗法,即 survodutide 和 cotadutide,在控制代谢相关性脂肪肝方面进行了评估。脂肪肾是内脏肥胖患者慢性肾病病理生理学中的另一个新概念。
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来源期刊
CiteScore
9.50
自引率
3.60%
发文量
192
审稿时长
1 months
期刊介绍: EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.
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