Are females getting more fatigable as they age?

IF 2.8 3区医学 Q2 PHYSIOLOGY

European Journal of Applied Physiology Pub Date : 2025-03-01 Epub Date: 2024-10-17 DOI:10.1007/s00421-024-05637-6

Mathilde Fiona Bertrand, Giorgio Varesco, Guillaume Y Millet, Léonard Féasson, Thomas Lapole, Vianney Rozand

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引用次数: 0

Abstract

Purpose: The aim of this study was to compare performance fatigability between young (n = 13; 18-35 yr.; 23.5 ± 3.3 yr.), old (n = 13; 60-79 yr.; 68.2 ± 4.3 yr.), and very old (n = 11; ≥ 80 yr.; 85.6 ± 1.8 yr.) females during single-limb isometric (ISO) vs. isokinetic concentric (CON) vs. cycling (BIKE) fatiguing tasks.

Methods: Participants randomly performed three incremental fatiguing tasks where increments were set as percentage of body weight to better reflect the daily life: (1) ISO and (2) CON consisted of stages of 75 contractions (120 s, 0.8 s on/0.8 s off) on an isokinetic dynamometer and (3) BIKE consisted of stages of 120 s at 37.5 rpm with similar duty cycle. Knee extensors maximal force, voluntary activation and potentiated twitch amplitude were measured at baseline, after each stage and at exhaustion.

Results: Compared to young, exercise performance was 20% and 53% lower in old and very old females in ISO, 46% and 76% lower in CON and 32% and 62% lower in BIKE (all p < 0.01). For a given workload (i.e. common stages), performance fatigability (i.e. force loss) was greater for very old compared to young females in CON only (p = 0.018). At exhaustion, performance fatigability was similar across groups and conditions (~ 30%; all p > 0.05), with similar impairments in both voluntary activation and twitch amplitude.

Conclusion: These results emphasize the importance of the kind of fatiguing task and modalities of evaluation when investigating the effects of aging on performance fatigability.

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女性是否越老越容易疲劳？

目的：本研究旨在比较年轻女性（n = 13；18-35 岁；23.5 ± 3.3 岁）、老年女性（n = 13；60-79 岁；68.2 ± 4.3 岁）和高龄女性（n = 11；≥ 80 岁；85.6 ± 1.8 岁）在单肢等长（ISO）与等动同心（CON）与骑自行车（BIKE）疲劳任务中的表现疲劳性：为了更好地反映日常生活，参与者随机进行了三种增量疲劳任务，增量设定为体重的百分比：(1) ISO 和 (2) CON 包括在等速测力计上进行 75 次收缩的阶段（120 秒，0.8 秒开/0.8 秒关）；(3) BIKE 包括在 37.5 转/分钟的速度下进行 120 秒的阶段，占空比相似。在基线、每个阶段后和力竭时测量膝关节伸肌最大力量、自主激活和增效抽搐幅度：与年轻人相比，老年和高龄女性在 ISO 中的运动表现分别降低了 20% 和 53%，在 CON 中分别降低了 46% 和 76%，在 BIKE 中分别降低了 32% 和 62%（均为 P 0.05），自主激活和抽动振幅均有类似的损伤：这些结果强调了在研究衰老对运动表现疲劳性的影响时，疲劳任务的类型和评估方式的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Applied Physiology 医学-生理学

CiteScore

6.00

自引率

6.70%

发文量

227

审稿时长

3 months

期刊介绍： The European Journal of Applied Physiology (EJAP) aims to promote mechanistic advances in human integrative and translational physiology. Physiology is viewed broadly, having overlapping context with related disciplines such as biomechanics, biochemistry, endocrinology, ergonomics, immunology, motor control, and nutrition. EJAP welcomes studies dealing with physical exercise, training and performance. Studies addressing physiological mechanisms are preferred over descriptive studies. Papers dealing with animal models or pathophysiological conditions are not excluded from consideration, but must be clearly relevant to human physiology.