Spectrum of hepatitis B and hepatitis C-related cancers in India.

IF 1.2 Q4 ONCOLOGY

ecancermedicalscience Pub Date : 2024-09-06 eCollection Date: 2024-01-01 DOI:10.3332/ecancer.2024.1760

Sivaranjini Kannusamy, Amey Oak, Sandhya Cheulkar, Kamesh Maske, Esha Dashmukhe, Ashwini Patil, Manisha Morajkar, Manju Sengar, Ganesh Balasubramaniam, Rajesh Dikshit

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Abstract

Introduction: Hepatitis-B virus infection contributes to 40%-50% of the Hepato-cellular carcinomas (HCC) in India, while hepatitis-C virus infection accounts for 12%-32% of cases. This study aimed at determining the patterns of cancers among patients with hepatitis B and C.

Materials and methods: This was a retrospective study of cancer patients with histologically proven diagnoses of cancer registered at Tata Memorial Hospital in Mumbai between 2017 and 2018. The proportional incidence ratio (PIR) was computed by dividing the observed number of site-specific cancer cases by the expected number.

Results: The study participants' mean (SD) age was 48.69 (±16.91) years with a male-to-female ratio of 1.36. The prevalence of hepatitis B and C was 1.93% and 1.17%, respectively. Liver cancer showed the highest occurrence rate with notably increased PIR among individuals positive for hepatitis B (males: 14.41, females: 10.89) and hepatitis C (males: 7.15, females: 10.42). Furthermore, hepatitis B-positive patients showed elevated PIR for haemato-lymphoid malignancies such as multiple myeloma and non-Hodgkin's lymphoma.

Limitation: The correlation between HBsAg and specific cancer types (PIRs) is limited by small case numbers, requiring careful interpretation of these findings.

Implications and conclusion: The PIR for liver cancer was heightened in both hepatitis B and C patients. Strengthened surveillance, including pre-screening for hepatitis B and C positive infection among cancer patients, as well as screening for HCCs among hepatitis seropositive individuals, is crucial to mitigate the incidence of HCC.

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印度乙型肝炎和丙型肝炎相关癌症的分布情况。

导言：在印度，乙型肝炎病毒感染导致的肝细胞癌（HCC）占 40%-50%，而丙型肝炎病毒感染导致的肝细胞癌（HCC）占 12%-32%。本研究旨在确定乙型肝炎和丙型肝炎患者的癌症模式：这是一项回顾性研究，研究对象是 2017 年至 2018 年期间在孟买塔塔纪念医院登记的经组织学证实确诊的癌症患者。比例发病率（PIR）的计算方法是将观察到的特定部位癌症病例数除以预期病例数：研究参与者的平均（标清）年龄为 48.69 (±16.91) 岁，男女比例为 1.36。乙型肝炎和丙型肝炎的发病率分别为 1.93% 和 1.17%。肝癌的发生率最高，乙型肝炎阳性者（男性：14.41，女性：10.89）和丙型肝炎阳性者（男性：7.15，女性：10.42）的肝癌发病率明显增高。此外，乙肝阳性患者罹患血液淋巴恶性肿瘤（如多发性骨髓瘤和非霍奇金淋巴瘤）的 PIR 值也有所升高：局限性：HBsAg与特定癌症类型（PIRs）之间的相关性因病例数较少而受到限制，需要仔细解释这些发现：乙型肝炎和丙型肝炎患者的肝癌 PIR 均有所升高。加强监测，包括预先筛查癌症患者中的乙型肝炎和丙型肝炎阳性感染者，以及筛查肝炎血清阳性者中的 HCC，对于降低 HCC 发病率至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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