Predictive significance of inflammatory markers in the survival of older Indian patients with cancer: a single-center prospective analysis.

IF 1.2 Q4 ONCOLOGY

ecancermedicalscience Pub Date : 2024-08-22 eCollection Date: 2024-01-01 DOI:10.3332/ecancer.2024.1746

Abhijith Rajaram Rao, Vanita Noronha, Anant Ramaswamy, Anbarasan Sekar, Anita Kumar, Anupa Pillai, Shreya Gattani, Arshiya Sehgal, Sharath Kumar, Renita Castelino, Ratan Dhekale, Jyoti Krishnamurthy, Sarika Mahajan, Anuradha Daptardar, Lekhika Sonkusare, Jayita Deodhar, Nabila Ansari, Manjusha Vagal, Purabi Mahajan, Shivshankar Timmanpyati, Manjunath Nookala, Ankita Chitre, Akhil Kapoor, Vikram Gota, Shripad Banavali, Rajendra A Badwe, Kumar Prabhash

{"title":"Predictive significance of inflammatory markers in the survival of older Indian patients with cancer: a single-center prospective analysis.","authors":"Abhijith Rajaram Rao, Vanita Noronha, Anant Ramaswamy, Anbarasan Sekar, Anita Kumar, Anupa Pillai, Shreya Gattani, Arshiya Sehgal, Sharath Kumar, Renita Castelino, Ratan Dhekale, Jyoti Krishnamurthy, Sarika Mahajan, Anuradha Daptardar, Lekhika Sonkusare, Jayita Deodhar, Nabila Ansari, Manjusha Vagal, Purabi Mahajan, Shivshankar Timmanpyati, Manjunath Nookala, Ankita Chitre, Akhil Kapoor, Vikram Gota, Shripad Banavali, Rajendra A Badwe, Kumar Prabhash","doi":"10.3332/ecancer.2024.1746","DOIUrl":null,"url":null,"abstract":"Aim: To evaluate the prognostic impact of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) on overall survival (OS) among Indian older patients with cancer.Methods: This observational study was conducted in the geriatric oncology clinic of Tata Memorial Hospital (India). We included all patients who underwent a geriatric assessment (GA) and had a complete blood count available for analysis. The NLR was dichotomized at 3.5, PLR and LMR at the median. Our primary study outcome was OS.Results: Between June 2018 and November 2021, 786 patients were enrolled (median age: 69 years). The most common primary tumour was lung (308, 39.5%), followed by gastrointestinal (261, 33.5%). Metastatic disease was present in 54.3% of patients. Univariate analysis revealed that patients with NLR >3.5 had shorter OS (9.1 months) than NLR <3.5 (15.7 months) (HR: 1.56). Similarly, patients with PLR >183.5 had reduced OS (9.3 months) compared to PLR <183.5 (16.6 months) (HR: 1.56). Conversely, patients with LMR >3.1 showed better OS (14.2) compared to LMR <3.1 (9.8 months) (HR: 0.74). After adjusting for age, performance status, primary tumour, metastatic status and GA-derived factors (function, nutrition and cognition), NLR (HR: 1.25, 95%CI: 1.03-1.52), PLR (HR: 1.34, 95%CI: 1.11-1.63) and LMR (HR: 0.79, 95%CI: 0.65-0.95) were associated with OS.Conclusion: In our study of older cancer patients, we identified three key inflammatory markers (NLR >3.5, PLR >183.5, LMR <3.1) as strong predictors of poor OS. These markers remain predictive even after accounting for traditional prognostic factors and GA-derived scales.","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"18 ","pages":"1746"},"PeriodicalIF":1.2000,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484672/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ecancermedicalscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3332/ecancer.2024.1746","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: To evaluate the prognostic impact of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) on overall survival (OS) among Indian older patients with cancer.

Methods: This observational study was conducted in the geriatric oncology clinic of Tata Memorial Hospital (India). We included all patients who underwent a geriatric assessment (GA) and had a complete blood count available for analysis. The NLR was dichotomized at 3.5, PLR and LMR at the median. Our primary study outcome was OS.

Results: Between June 2018 and November 2021, 786 patients were enrolled (median age: 69 years). The most common primary tumour was lung (308, 39.5%), followed by gastrointestinal (261, 33.5%). Metastatic disease was present in 54.3% of patients. Univariate analysis revealed that patients with NLR >3.5 had shorter OS (9.1 months) than NLR <3.5 (15.7 months) (HR: 1.56). Similarly, patients with PLR >183.5 had reduced OS (9.3 months) compared to PLR <183.5 (16.6 months) (HR: 1.56). Conversely, patients with LMR >3.1 showed better OS (14.2) compared to LMR <3.1 (9.8 months) (HR: 0.74). After adjusting for age, performance status, primary tumour, metastatic status and GA-derived factors (function, nutrition and cognition), NLR (HR: 1.25, 95%CI: 1.03-1.52), PLR (HR: 1.34, 95%CI: 1.11-1.63) and LMR (HR: 0.79, 95%CI: 0.65-0.95) were associated with OS.

Conclusion: In our study of older cancer patients, we identified three key inflammatory markers (NLR >3.5, PLR >183.5, LMR <3.1) as strong predictors of poor OS. These markers remain predictive even after accounting for traditional prognostic factors and GA-derived scales.

查看原文本刊更多论文

炎症标志物对印度老年癌症患者生存期的预测意义：一项单中心前瞻性分析。

目的：评估中性粒细胞-淋巴细胞比率（NLR）、血小板-淋巴细胞比率（PLR）和淋巴细胞-单核细胞比率（LMR）对印度老年癌症患者总生存期（OS）的预后影响：这项观察性研究在印度塔塔纪念医院的老年肿瘤诊所进行。我们纳入了所有接受老年病学评估（GA）并有全血细胞计数可供分析的患者。NLR为3.5，PLR和LMR为中位数。我们的主要研究结果是OS.Results：2018年6月至2021年11月期间，共有786名患者入组（中位年龄：69岁）。最常见的原发肿瘤是肺癌（308例，39.5%），其次是胃肠道肿瘤（261例，33.5%）。54.3%的患者存在转移性疾病。单变量分析显示，与 NLR 183.5 相比，NLR >3.5 患者的 OS 缩短（9.1 个月）；与 PLR 3.1 相比，NLR 183.5 患者的 OS 缩短（9.3 个月）；与 LMR 相比，NLR 3.1 患者的 OS 改善（14.2 个月）：在我们对老年癌症患者的研究中，我们发现了三种关键的炎症标志物（NLR >3.5、PLR >183.5、LMR

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊