Recent Evidence of Non-Rapid Eye Movement Sleep Oscillation Abnormalities in Psychiatric Disorders.

IF 5.5 2区医学 Q1 PSYCHIATRY

Current Psychiatry Reports Pub Date : 2024-10-14 DOI:10.1007/s11920-024-01544-x

Ahmad Mayeli, Claudio Sanguineti, Fabio Ferrarelli

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引用次数: 0

Abstract

Purpose of review: We review recent studies published from 2019 to 2024 examining slow waves and sleep spindles abnormalities across neurodevelopmental, mood, trauma-related, and psychotic disorders using polysomnography and Electroencephalogram (EEG).

Recent findings: Individuals with attention-deficit/hyperactivity disorder (ADHD) showed higher slow-spindle activity, while findings on slow-wave activity were mixed. Individuals with autism spectrum disorder (ASD) showed inconsistent results with some evidence of lower spindle chirp and slow-wave amplitude. Individuals with depression displayed lower slow-wave and spindle parameters mostly in medicated patients. Individuals with post-traumatic stress disorder (PTSD) showed higher spindle frequency and activity, which were associated with their clinical symptoms. Psychotic disorders demonstrated the most consistent alterations, with lower spindle density, amplitude, and duration across illness stages that correlated with patients' symptom severity and cognitive deficits, whereas lower slow-wave measures were present in the early phases of the disorders. Sleep spindle and slow-wave abnormalities are present across psychiatric populations, with the most consistent alterations observed in psychotic disorders. Larger studies with standardized methodologies and longitudinal assessments are needed to establish the potential of these oscillations as neurophysiological biomarkers and/or treatment targets.

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精神病患者非快速眼动睡眠振荡异常的最新证据。

综述目的：我们回顾了2019年至2024年发表的最新研究，这些研究使用多导睡眠图和脑电图（EEG）检查了神经发育障碍、情绪障碍、创伤相关障碍和精神障碍患者的慢波和睡眠纺锤体异常：最近的研究结果：注意力缺陷/多动障碍（ADHD）患者的慢纺锤活动较高，而慢波活动的研究结果不一。自闭症谱系障碍（ASD）患者的结果不一致，有证据表明纺锤体鸣响和慢波振幅较低。抑郁症患者的慢波和纺锤体参数较低，主要表现在药物治疗患者身上。创伤后应激障碍（PTSD）患者的纺锤体频率和活动较高，这与他们的临床症状有关。精神病性障碍的改变最为一致，不同疾病阶段的纺锤体密度、振幅和持续时间均较低，这与患者的症状严重程度和认知缺陷有关，而在疾病的早期阶段，慢波测量值较低。睡眠纺锤体和慢波异常存在于所有精神病患者中，在精神病性障碍中观察到的改变最为一致。需要通过标准化方法和纵向评估进行更大规模的研究，以确定这些振荡作为神经生理学生物标志物和/或治疗目标的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Psychiatry Reports PSYCHIATRY-

CiteScore

11.30

自引率

3.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published research in psychiatry. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by psychiatric disorders. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anxiety, medicopsychiatric disorders, and schizophrenia and other related psychotic disorders. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.