Choroidal structural changes in inactive thyroid eye disease: a cross-sectional analysis of the choroidal vascularity index.

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY
Serhat Ermiş, Ece Özal, Fatma Savur, Murat Karapapak
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引用次数: 0

Abstract

Objective: In this study, we aimed to compare choroidal vascular changes using the Choroidal Vascularity Index (CVI) between patients with inactive Thyroid Eye Disease (iTED) and healthy individuals, and to assess the relationship between CVI and choroidal thickness (CT), smoking history, and clinical parameters.

Methods: In this cross-sectional observational study, the eyes of 30 patients aged 18 to 45 with iTED were compared with the randomly selected eyes of 35 age and gender-matched healthy control individuals. Optical coherence tomography (OCT) scans were taken from all participants. The images were binarized using the ImageJ software, and the total choroidal area (TCA) and luminal area (LA) were measured. The ratio of the LA to the TCA was used to calculate the CVI. The relationships between these measurement parameters and clinical activity score (CAS), exophthalmometry, smoking status, and other clinical parameters were examined.

Results: In the iTED group, CT and CVI values were significantly higher compared to the control group (p < 0.001, p = 0.029). No significant effect of smoking on choroidal parameters was detected in the iTED group. Additionally, there was no statistical correlation between choroidal parameters and either exophthalmometry or CAS (p > 0.05). In the multivariate regression analysis, it was determined that CT showed a significant relationship with thyroid stimulating immunoglobulin (TSI) (p = 0.003).

Conclusions: This study found that CT and CVI were increased in the eyes of patients with iTED compared to healthy controls. The history of smoking did not appear to have any effect on CT and CVI in iTED patients.

非活动性甲状腺眼病的脉络膜结构变化:脉络膜血管指数的横断面分析。
研究目的本研究旨在使用脉络膜血管指数(CVI)比较非活动性甲状腺眼病(iTED)患者与健康人之间的脉络膜血管变化,并评估CVI与脉络膜厚度(CT)、吸烟史和临床参数之间的关系:在这项横断面观察性研究中,30 名 18 至 45 岁的 iTED 患者的眼睛与随机选取的 35 名年龄和性别匹配的健康对照者的眼睛进行了比较。所有参与者都进行了光学相干断层扫描(OCT)。使用 ImageJ 软件对图像进行二值化处理,并测量脉络膜总面积(TCA)和管腔面积(LA)。LA 与 TCA 之比用于计算 CVI。研究了这些测量参数与临床活动评分(CAS)、眼外伤测量、吸烟状况和其他临床参数之间的关系:在 iTED 组中,CT 和 CVI 值明显高于对照组(P 0.05)。在多变量回归分析中,CT 与促甲状腺免疫球蛋白(TSI)有显著关系(P = 0.003):本研究发现,与健康对照组相比,iTED 患者眼部的 CT 和 CVI 均有所增加。吸烟史似乎对 iTED 患者的 CT 和 CVI 没有任何影响。
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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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