Cellular Senescence and Anti-Aging Strategies in Aesthetic Medicine: A Bibliometric Analysis and Brief Review.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-10-09 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S403417

Huilan Zheng, Jingping Wu, Jinhong Feng, Hongbin Cheng

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引用次数: 0

Abstract

Background: Skin aging is the most obvious feature of human aging, and delaying aging has become a hot and difficult research topic in aesthetic medicine. The accumulation of dysfunctional senescent cells is one of the important mechanisms of skin aging, based on which a series of anti-aging strategies have been generated. In this paper, from the perspective of cellular senescence, we utilize bibliometrics and research review to explore the research hotspots and trends in this field, with a view to providing references for skin health and aesthetic medicine.

Methods: We obtained literature related to this field from the Web of Science Core Collection database from 1994 to 2024. Bibliometrix packages in R, CiteSpace, VOSviewer, Origin, and Scimago Graphica were utilized for data mining and visualization.

Results: A total of 2,796 documents were included in the analysis. The overall trend of publications showed a continuous and rapid increase from 2016-2023, but the total citations improved poorly over time. In this field, Journal of Cosmetic Dermatology, Journal of Investigative Dermatology, Experimental Gerontology are core journals. Kim J, Lee JH, Lee S, Rattan SIS, Chung JH and Kim JH are the core authors in this field. Seoul National University is the first in terms of publications. Korea is the country with the most publications, but USA has the most total citations. Top 10 keywords include: gene-expression, skin, cellular senescence, cell, oxidative stress, antioxidants, in vitro, fibroblasts, mechanism, cancer. Current research trends are focused on neurodegeneration, skin rejuvenation, molecular docking, fibrosis, wound healing, SASP, skin barrier, and antioxidants. The core literature and references reflect topics such as the major molecular pathways in the aging process, and the relationship with tumors.

Conclusion: This field of research has been rapidly rising in recent years. Relevant research hotspots focus on oxidative stress, fibroblasts, and senescence-associated secretory phenotype. Anti-aging strategies targeting cellular senescence hold great promise, including removal of senescent cells or attenuation of SASP factors, corresponding to senolytics and senomorphics therapies, respectively.

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美容医学中的细胞衰老与抗衰老策略：文献计量分析与简评》。

背景：皮肤衰老是人体衰老最明显的特征，延缓衰老已成为美容医学研究的热点和难点。功能失调性衰老细胞的堆积是皮肤衰老的重要机制之一，在此基础上产生了一系列抗衰老策略。本文从细胞衰老的角度，利用文献计量学和研究综述的方法，探讨该领域的研究热点和趋势，以期为皮肤健康和美容医学提供参考：我们从 Web of Science Core Collection 数据库中获取了 1994 年至 2024 年与该领域相关的文献。我们使用 R、CiteSpace、VOSviewer、Origin 和 Scimago Graphica 中的 Bibliometrix 软件包进行数据挖掘和可视化：结果：共有 2,796 篇文献被纳入分析。2016-2023年，论文发表量总体呈持续快速增长趋势，但总被引频次随时间推移改善不明显。在该领域，《Journal of Cosmetic Dermatology》、《Journal of Investigative Dermatology》、《Experimental Gerontology》为核心期刊。Kim J、Lee JH、Lee S、Rattan SIS、Chung JH 和 Kim JH 是该领域的核心作者。首尔国立大学在发表论文方面位居第一。韩国是发表论文最多的国家，但美国的总引用次数最多。排名前十的关键词包括：基因表达、皮肤、细胞衰老、细胞、氧化应激、抗氧化剂、体外、成纤维细胞、机制、癌症。目前的研究趋势主要集中在神经变性、皮肤年轻化、分子对接、纤维化、伤口愈合、SASP、皮肤屏障和抗氧化剂等方面。核心文献和参考文献反映了衰老过程中的主要分子途径以及与肿瘤的关系等主题：该研究领域近年来迅速崛起。相关研究热点集中在氧化应激、成纤维细胞和衰老相关分泌表型。针对细胞衰老的抗衰老策略大有可为，包括清除衰老细胞或减弱 SASP 因子，分别对应于衰老溶解剂疗法和衰老形态学疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.