Impairment of Internal Auditory Canal Barrier in Meniere's Disease.

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2024-10-20 DOI:10.1111/coa.14242

Weidong Zhang, Jiapei Xie, Songbai Li, Bo Zhang

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引用次数: 0

Abstract

Objective: The aim of this investigation was to explore the potential correlation between the signal intensity ratio (SIR) at the internal auditory canal (IAC) fundus and hearing impairment in Meniere's disease (MD), thereby providing a foundation to further understand the mechanisms underlying hearing loss.

Design: Fifty patients diagnosed with unilateral definite MD were enrolled in the study. 3D-FLAIR MRI was conducted 4 h after intravenous administration of gadobutrol to determine the SIR of the bilateral IAC fundus. The difference in the SIR of the IAC fundus between the affected and unaffected sides was assessed, followed by an analysis of its correlation with low-, middle-, and high-tone hearing thresholds. Correlation analysis was also conducted between the degree of endolymphatic hydrops (EH) in the vestibule and cochlea and the SIR on the affected side.

Results: The degree of EH in MD can be clearly visualised using 3D-FLAIR MRI. The SIR on the affected side was significantly higher than that on the unaffected side (p = 0.000). Furthermore, a positive correlation was observed between the SIR at the affected and low (r = 0.692, p = 0.000), middle (r = 0.615, p = 0.000) and high-tone (r = 0.440, p = 0.001) hearing thresholds, while the SIR showed no significant correlation with cochlear (r = 0.315, p = 0.088) or vestibular hydrops (r = 0.215, p = 0.244).

Conclusion: The IAC fundus barrier may be damaged in patients with MD, representing one of the factors affecting the level of hearing.

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梅尼埃病的内听道屏障损伤

研究目的本研究旨在探讨梅尼埃病（MD）患者内耳道底信号强度比（SIR）与听力损伤之间的潜在相关性，从而为进一步了解听力损失的内在机制奠定基础：设计：50 名确诊为单侧梅尼埃病的患者参与了研究。静脉注射钆布醇 4 小时后进行三维-FLAIR MRI，以确定双侧 IAC 基底的 SIR。评估受影响侧和未受影响侧 IAC 基底 SIR 的差异，然后分析其与低音、中音和高音听阈的相关性。此外，还对前庭和耳蜗的内淋巴水肿（EH）程度与患侧的 SIR 进行了相关性分析：结果：使用 3D-FLAIR MRI 可以清楚地观察到 MD 的 EH 程度。患侧的 SIR 明显高于未患侧的（p = 0.000）。此外，患侧的 SIR 与低音（r = 0.692，p = 0.000）、中音（r = 0.615，p = 0.000）和高音（r = 0.440，p = 0.001）听阈之间呈正相关，而 SIR 与耳蜗（r = 0.315，p = 0.088）或前庭水肿（r = 0.215，p = 0.244）无明显相关性：结论：MD 患者的 IAC 眼底屏障可能受损，是影响听力水平的因素之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.