Metabolomics: Unveiling biological matrices in precision nutrition and health

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2024-10-18 DOI:10.1016/j.clnesp.2024.10.148

Bruna Lima Chechin Catussi , Edson Guimarães Lo Turco , Dirceu Mendes Pereira , Rafael Matheus Nunes Teixeira , Bárbara Prestes Castro , Irineu Francisco Delfino Massaia

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引用次数: 0

Abstract

Precision nutrition, an expanding field at the intersection of nutrition science and personalized medicine, is rapidly evolving with metabolomics integration. Metabolomics, facilitated by advanced technologies like mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, facilitates comprehensive profiling of metabolites across diverse biological samples. From the perspective of health care systems, precision nutrition gains relevance due to the substantial impact of prevalent non-communicable diseases (NCDs) on societal well-being, which is directly linked with dietary habits and eating behavior. Furthermore, biomarker products derived from metabolomics have been utilized in Europe, the USA, and Brazil to understand metabolic dysregulations and tailor diets accordingly. Despite its burgeoning status, metabolomics holds great potential in revolutionizing nutritional science, particularly with the integration of artificial intelligence and machine learning, offering novel insights into personalized dietary interventions and disease prediction. This narrative review emphasizes the transformative impact of metabolomics in precision and delineates avenues for future research and application, paving the way for a more tailored and practical approach to nutrition management.

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代谢组学：揭示精准营养与健康中的生物基质。

精准营养是营养科学与个性化医疗交汇的一个不断扩大的领域，正随着代谢组学的整合而迅速发展。代谢组学在质谱（MS）和核磁共振（NMR）光谱等先进技术的推动下，有助于对不同生物样本中的代谢物进行全面分析。从医疗保健系统的角度来看，由于流行性非传染性疾病（NCDs）对社会福祉产生了重大影响，而这种影响又与饮食习惯和饮食行为直接相关，因此精准营养变得越来越重要。此外，欧洲、美国和巴西已利用代谢组学衍生的生物标志物产品来了解代谢失调，并据此调整饮食。尽管代谢组学的发展方兴未艾，但它在营养科学的变革中仍具有巨大的潜力，尤其是与人工智能和机器学习的结合，为个性化膳食干预和疾病预测提供了新的见解。这篇叙述性综述强调了代谢组学在精准方面的变革性影响，并勾勒了未来研究和应用的途径，为更有针对性、更实用的营养管理方法铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.