Bipolar disorder among individuals with atopic dermatitis: a case-control study in the All of Us Research Program.

IF 3.7 4区医学 Q1 DERMATOLOGY

Clinical and Experimental Dermatology Pub Date : 2025-03-26 DOI:10.1093/ced/llae451

Anthony Mitchel Wride, Gloria F Chen, Ryan Fan, Audrey C Leasure, Stephen Scott Jones, Daniel F Levey, William Damsky, Jeffrey M Cohen

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引用次数: 0

Abstract

Background: Atopic dermatitis (AD) has been associated with psychiatric comorbidities.

Objectives: To characterize the association between AD and bipolar disorder (BPD) with a case-control study of the National Institutes of Health All of Us Research Program.

Methods: We used Systematized Nomenclature of Medicine diagnostic codes to identify cases of AD. Four age-, sex- and race/ethnicity-matched controls were found for each case using propensity score matching. After controlling for age, sex, race/ethnicity, income, smoking status and depression, the relationship between AD and BPD was evaluated using logistic regression.

Results: We identified 13 431 AD cases and 53 724 matched controls. Participants with AD were more likely than controls to have BPD (7.8% vs. 4.6%, P < 0.001). After adjusting for demographics and comorbidities, we observed a significant association (odds ratio 1.49, 95% confidence interval 1.37-1.62; P < 0.001).

Conclusions: Compared with individuals without AD, individuals with AD have 1.49-fold increased odds of having BPD. Further investigation is needed to gain a better understanding of this association.

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特应性皮炎患者中的躁郁症：我们所有人研究计划中的一项病例对照研究。

背景：特应性皮炎（AD）与精神疾病有关：特应性皮炎（AD）与精神病合并症有关：通过美国国立卫生研究院 "我们所有人 "研究项目的病例对照研究，确定特应性皮炎与双相情感障碍（BPD）之间的关系：方法：利用系统化医学术语诊断代码，我们确定了注意力缺失症病例。利用倾向得分匹配法为每个病例找到四个年龄、性别和种族/民族匹配的对照组。在对年龄、性别、种族/民族、收入、吸烟状况和抑郁进行控制后，我们使用逻辑回归法评估了 AD 与 BPD 之间的关系：结果：我们发现了 13,431 例注意力缺失症病例和 53,724 例匹配对照。与对照组相比，AD 患者更有可能患有 BPD（7.8% 对 4.6%，PC）：与非 AD 患者相比，AD 患者患 BPD 的几率增加了 1.49 倍。要进一步了解这种关联，还需要进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

2.40%

发文量

389

审稿时长

3-8 weeks

期刊介绍： Clinical and Experimental Dermatology (CED) is a unique provider of relevant and educational material for practising clinicians and dermatological researchers. We support continuing professional development (CPD) of dermatology specialists to advance the understanding, management and treatment of skin disease in order to improve patient outcomes.