Investigating the association between the GAP-43 concentration with diffusion tensor imaging indices in Alzheimer's dementia continuum.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

BMC Neurology Pub Date : 2024-10-17 DOI:10.1186/s12883-024-03904-9

Armin Ariaei, Atousa Ghorbani, Elham Habibzadeh, Nazanin Moghaddam, Negar Chegeni Nezhad, Amirabbas Abdoli, Samira Mazinanian, Mohammad Sadeghi, Mahsa Mayeli

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引用次数: 0

Abstract

Background: Synaptic degeneration, axonal injury, and white matter disintegration are among the pathological events in Alzheimer's disease (AD), for which growth-associated protein 43 (GAP-43) and diffusion tensor imaging (DTI) could be an indicator. In this study, the cerebrospinal fluid (CSF) GAP-43 clinical trajectories and their association with progression and AD hallmarks with white matter microstructural changes were evaluated.

Methods: A total number of 133 participants were enrolled in GAP-43 and DTI values were compared between groups, both cross-sectionally and longitudinally with two and four-year follow-ups. Subsequently, the correlation between GAP-43 levels in the CSF and DTI values was investigated using Spearman's correlation.

Results: The CSF level of GAP-43 is negatively correlated with the mean diffusivity measures in Fornix (Cres)/Stria terminals in early and late MCI (r_s=-0.478 p = 0.021 and r_s=-0.425 p = 0.038). Additionally, the CSF level of GAP-43 is negatively correlated with fractional anisotropy in the cingulum in late MCI (r_s=-0.437 p = 0.033). Moreover, the axial diffusivity in superior corona radiate (r_s=-0.562 p = 0.005 and r_s=-0.484 p = 0.036) and radial diffusivity in superior fronto-occipital fasciculus was negatively correlated with GAP-43 level in the early and mid-MCI participants (r_s=-0.520 p = 0.011 and r_s=-0.498 p = 0.030).

Conclusions: Presynaptic marker GAP-43 in combination with DTI can be used as a novel biomarker to identify microstructural synaptic degeneration in the early MCI. In addition, it can be used as a biomarker for tracking the progression of AD and monitoring treatment efficacy.

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研究阿尔茨海默氏症连续性痴呆症中 GAP-43 浓度与弥散张量成像指数之间的关联。

背景：突触变性、轴突损伤和白质破坏是阿尔茨海默病（AD）的病理特征之一，而生长相关蛋白 43（GAP-43）和弥散张量成像（DTI）可作为其指标。本研究评估了脑脊液（CSF）GAP-43的临床轨迹及其与进展和AD特征与白质微结构变化的关系：方法：共有 133 名参与者参加了 GAP-43 研究，并在两年和四年的随访中横向和纵向比较了各组之间的 DTI 值。随后，利用斯皮尔曼相关性研究了脑脊液中 GAP-43 水平与 DTI 值之间的相关性：结果：GAP-43的CSF水平与早期和晚期MCI患者Fornix (Cres)/Stria末端的平均弥散度呈负相关（rs=-0.478 p = 0.021和rs=-0.425 p = 0.038）。此外，在晚期 MCI 中，GAP-43 的 CSF 水平与脑室各向异性分数呈负相关（rs=-0.437 p = 0.033）。此外，在早期和中期MCI患者中，放射状上冠的轴向扩散率（rs=-0.562 p = 0.005和rs=-0.484 p = 0.036）和枕前上筋膜的径向扩散率与GAP-43水平呈负相关（rs=-0.520 p = 0.011和rs=-0.498 p = 0.030）：结论：突触前标记物GAP-43与DTI相结合可作为一种新型生物标记物，用于识别早期MCI患者的微结构突触退化。结论：突触前标记物 GAP-43 与 DTI 结合可作为一种新型生物标记物，用于识别早期 MCI 的微结构突触退化，此外，它还可作为一种生物标记物，用于追踪 AD 的进展和监测治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Neurology 医学-临床神经学

CiteScore

4.20

自引率

0.00%

发文量

428

审稿时长

3-8 weeks

期刊介绍： BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.