Intracranial pressure affects retinal venular complexity in idiopathic intracranial hypertension: a retrospective observational study.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

BMC Neurology Pub Date : 2024-10-19 DOI:10.1186/s12883-024-03881-z

Le Cao, Hang Wang, William Robert Kwapong, Zhouwei Xiong, Yitian Zhao, Guina Liu, Rui Liu, Junfeng Liu, Fayun Hu, Bo Wu

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引用次数: 0

Abstract

Background: Increased intracranial pressure (ICP) in patients with idiopathic intracranial hypertension (IIH) affects the retinal microvasculature, which can be imaged and quantified by optical coherence tomography angiography (OCTA). We aimed to identify the mediating factor between ICP and OCTA parameters association in IIH patients.

Methods: IIH patients with active intracranial hypertension were enrolled. OCTA imaging was performed after ICP measurement. We quantified the branching complexity of the retinal arterioles and venules from the superficial vascular complex of the OCTA image. Eyes of IIH patients were stratified into eyes with papilledema (IIH-P) and eyes without papilledema (IIH-WP). All participants underwent visual acuity (VA) examination.

Results: One hundred and thirty-eight eyes from 70 IIH patients and 146 eyes from 73 controls were included. Compared to the control group, IIH patients and IIH-P had reduced arteriole complexity and increased venule complexity (p < 0.05). For IIH patients and IIH-P, increased retinal venule complexity correlated with increased ICP and reduced VA (p < 0.05); while decreased arteriole complexity only correlated with Frisen scores (p = 0.026). Papilledema mediated the effect (p < 0.001) between ICP and arteriole complexity while ICP had a direct effect (p < 0.001) on venule complexity.

Conclusion: Retinal venules imaged via OCTA may reflect ICP levels and may underpin the direct effect of increased ICP in IIH patients.

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颅内压对特发性颅内高压症视网膜静脉复杂性的影响：一项回顾性观察研究。

背景：特发性颅内高压（IIH）患者的颅内压（ICP）升高会影响视网膜微血管，而光学相干断层血管成像（OCTA）可以对其进行成像和量化。我们的目的是找出 IIH 患者 ICP 与 OCTA 参数关联的中介因素：方法：我们招募了患有活动性颅内高压的 IIH 患者。在ICP测量后进行OCTA成像。我们从 OCTA 图像的表层血管复合体中量化了视网膜动静脉分支的复杂性。IIH 患者的眼睛被分为有乳头水肿的眼睛（IIH-P）和无乳头水肿的眼睛（IIH-WP）。所有参与者都接受了视力（VA）检查：结果：共纳入70名IIH患者的138只眼睛和73名对照组患者的146只眼睛。与对照组相比，IIH 患者和 IIH-P 患者的动脉复杂性降低，静脉复杂性升高（P 结语）：通过 OCTA 扫描的视网膜静脉可反映 ICP 水平，并可支持 IIH 患者 ICP 增高的直接影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Neurology 医学-临床神经学

CiteScore

4.20

自引率

0.00%

发文量

428

审稿时长

3-8 weeks

期刊介绍： BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.