Anti-dopamine receptor 2 antibody encephalitis in adults: a case report.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

BMC Neurology Pub Date : 2024-10-18 DOI:10.1186/s12883-024-03893-9

Xiaoke Wu, Mengmeng Shi, Haifeng Zhang

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引用次数: 0

Abstract

Background: Anti-dopamine receptor 2 (D2R) antibody encephalitis (D2R encephalitis) is a subtype of autoimmune encephalitis (AE). Lesions in affected patients primarily involve the basal ganglia, resulting in a range of psychiatric and movement disorders. A majority of cases reported to date have impacted children or adolescents, whereas we here describe a case of adult-onset D2R encephalitis.

Case presentation: A 30-year-old female patient affected by insomnia, recent memory impairment, bradykinesia, decreased responsivity, increased muscular tone of the extremities, and involuntary shaking of the right limb. Magnetic resonance imaging (MRI) of the basal ganglia did not reveal any notable findings, and both serum and cerebrospinal fluid were positive for antibodies specific for D2R. D2R encephalitis was diagnosed following the exclusion of other diseases. The patient's symptoms improved significantly with immunotherapeutic treatment, and she recovered fully over a 6-month follow-up period.

Conclusions: D2R is a new form of AE that can develop in adults and can be effectively treated via immunotherapy.

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成人抗多巴胺受体 2 抗体脑炎：病例报告。

背景：抗多巴胺受体 2（D2R）抗体脑炎（D2R脑炎）是自身免疫性脑炎（AE）的一种亚型。患者的病变主要累及基底神经节，导致一系列精神和运动障碍。迄今报道的大多数病例影响的是儿童或青少年，而我们在此描述的是一例成人发病的 D2R脑炎：一名 30 岁女性患者，失眠、近期记忆力减退、运动迟缓、反应迟钝、四肢肌肉张力增高、右侧肢体不自主颤抖。基底节的磁共振成像（MRI）没有发现任何明显的病变，血清和脑脊液中的 D2R 特异性抗体均呈阳性。在排除其他疾病后，确诊为 D2R 脑炎。经过免疫治疗，患者的症状明显好转，随访 6 个月后完全康复：结论：D2R是一种可在成人中发病的新型AE，可通过免疫疗法进行有效治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Neurology 医学-临床神经学

CiteScore

4.20

自引率

0.00%

发文量

428

审稿时长

3-8 weeks

期刊介绍： BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.