Bioelectrical impedance analysis-derived phase angle predicts possible Sarcopenia in patients on maintenance hemodialysis: a retrospective study.

IF 2.2 4区 医学 Q2 UROLOGY & NEPHROLOGY
Ying Zeng, Yang Chen, Yujie Yang, Ying Qiu, Ping Fu, Huaihong Yuan
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引用次数: 0

Abstract

Background: The prevalence of possible sarcopenia is notably high among maintenance hemodialysis (MHD) patients. Possible sarcopenia, defined as a decrease in muscle strength and/or somatic function, is an early and reversible condition between non-sarcopenic and sarcopenia, and early recognition and intervention for possible sarcopenia is important for preventing adverse outcomes and improving the quality of life of these patients. This study aimed to establish a simple and effective model for screening and identifying MHD patients at high risk of possible sarcopenia by using 50 kHz-Whole Body Phase Angle (PhA), with a specific focus on gender differences.

Methods: This prospective cross-sectional study was conducted from September to December 2023 at the Wenjiang Hemodialysis Center in the Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China. A total of 244 MHD patients, including 130 males and 114 females, were enrolled. Data were collected prospectively, including demographic information and physical measurements. All participants provided informed consent before enrollment. Measurements were taken post-dialysis to ensure consistency. The whole-body phase angle was measured using the InBody S10 device, grip strength was measured using an electronic grip strength tester, and physical function was assessed by the Short Physical Performance Battery (SPPB). The Skeletal Muscle Index (SMI) was also calculated.

Results: A total of 244 patients receiving hemodialysis were enrolled in this study. Among these, 109 patients were categorized as non-sarcopenic, 111 as having possible sarcopenia, and 24 as sarcopenic. The prevalence of sarcopenia among MHD patients is 9.8%, while the prevalence of possible sarcopenia is 45.5%. The receiver operating characteristic (ROC) curve analysis showed that for male patients, the AUC of PhA for predicting possible sarcopenia was 0.798, with a sensitivity of 80.36%, specificity of 69.70%, and a cutoff value of 6.20°. For female patients, the AUC of PhA was 0.701, with a sensitivity of 70.91% and specificity of 62.79%, and a cutoff value of 5.70°.

Conclusions: PhA may be a useful and simple predictor of the risk of possible sarcopenia in MHD patients, and more research is needed to further promote the use of PhA in possible sarcopenia.

生物电阻抗分析得出的相位角可预测维持性血液透析患者可能出现的肌少症:一项回顾性研究。
背景:在维持性血液透析(MHD)患者中,可能出现的 "肌肉疏松症 "发病率很高。可能的肌肉疏松症定义为肌肉力量和/或躯体功能下降,是介于非肌肉疏松症和肌肉疏松症之间的一种早期可逆情况,早期识别和干预可能的肌肉疏松症对于预防不良后果和改善这些患者的生活质量非常重要。本研究旨在利用 50 kHz 全身相位角(PhA)建立一个简单有效的模型,用于筛查和识别可能患有肌少症的高危 MHD 患者,并特别关注性别差异:这项前瞻性横断面研究于 2023 年 9 月至 12 月在中国成都四川大学华西医院肾内科温江血液透析中心进行。共纳入 244 名血液透析患者,包括 130 名男性和 114 名女性。前瞻性收集数据,包括人口统计学信息和体格测量。所有参与者在入组前均已知情同意。透析后进行测量以确保一致性。全身相位角使用 InBody S10 设备进行测量,握力使用电子握力测试仪进行测量,身体功能通过短期体能测试(SPPB)进行评估。此外,还计算了骨骼肌指数(SMI):共有 244 名接受血液透析的患者参与了这项研究。其中,109 名患者被归类为非肌肉疏松症患者,111 名患者被归类为可能患有肌肉疏松症,24 名患者被归类为肌肉疏松症患者。肌肉疏松症患者的发病率为 9.8%,而可能患有肌肉疏松症的发病率为 45.5%。接收器操作特征曲线(ROC)分析显示,对于男性患者,PhA 预测可能肌少症的 AUC 为 0.798,灵敏度为 80.36%,特异度为 69.70%,临界值为 6.20°。对于女性患者,PhA 的 AUC 为 0.701,灵敏度为 70.91%,特异度为 62.79%,临界值为 5.70°:PhA可能是预测MHD患者可能出现肌少症风险的一个有用而简单的指标,需要更多的研究来进一步促进PhA在可能出现的肌少症中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Nephrology
BMC Nephrology UROLOGY & NEPHROLOGY-
CiteScore
4.30
自引率
0.00%
发文量
375
审稿时长
3-8 weeks
期刊介绍: BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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