Utilizing stimuli-responsive nanoparticles to deliver and enhance the anti-tumor effects of bilirubin

IF 12.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology advances Pub Date : 2024-10-18 DOI:10.1016/j.biotechadv.2024.108469

Elaheh Mirhadi , Alexandra E. Butler , Prashant Kesharwani , Amirhossein Sahebkar

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Abstract

Bilirubin (BR) is among the most potent endogenous antioxidants that originates from the heme catabolic pathway. Despite being considered as a dangerous and cytotoxic waste product at high concentrations, BR has potent antioxidant effects leading to the reduction of oxidative stress and inflammation, which play an important role in the development and progression of cancer. The purpose of this study is to introduce PEGylated BR nanoparticles (NPs), themselves or in combination with other anti-cancer agents. BR is effective when loaded into various nanoparticles and used in cancer therapy. Interestingly, BRNPs can be manipulated to create stimuli-responsive carriers providing a sustained and controlled, as well as on-demand, release of drug in response to internal or external factors such as reactive oxygen species, glutathione, light, enzymes, and acidic pH. This review suggests that BRNPs have the potential as tumor microenvironment-responsive delivery systems for effective targeting of various types of cancers.

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利用刺激响应型纳米粒子传递和增强胆红素的抗肿瘤效果。

胆红素（BR）是源自血红素分解途径的最有效的内源性抗氧化剂之一。尽管胆红素在高浓度时被认为是一种危险的细胞毒性废物，但它具有非凡的抗氧化作用，可减少氧化应激和炎症，而氧化应激和炎症在癌症的发生和发展中起着重要作用。本研究的目的是引入聚乙二醇化 BR 纳米粒子（NPs）本身或与其他抗癌剂结合使用。在癌症治疗中，BR 被载入各种纳米颗粒后，效果显著。有趣的是，BRNPs 可被操纵以创建刺激响应载体，从而根据活性氧、谷胱甘肽、光、酶和酸性 pH 值等内部或外部因素，提供持续、可控和按需的药物释放。综上所述，BRNPs 具有作为肿瘤微环境响应型递送系统的潜力，可有效针对各种癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnology advances 工程技术-生物工程与应用微生物

CiteScore

25.50

自引率

2.50%

发文量

167

审稿时长

37 days

期刊介绍： Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.