Investigating Olfactory Sensory Neurons Facilitation For Aerobic Exercise-induced Spatial Memory Improvement.

IF 1 Q4 NEUROSCIENCES

Basic and Clinical Neuroscience Pub Date : 2024-05-01 DOI:10.32598/bcn.2022.4029.1

Farzaneh Zeynali, Mohammad Reza Raoufy, Reza Gharakhanlou

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引用次数: 0

Abstract

Introduction: The positive effects of exercise on spatial memory and learning have been demonstrated in research. The olfactory sensory neurons (OSNs) respond to mechanical stimulation induced by nasal airflow which is associated with airflow intensity. Accordingly, nasal breathing can modulate brain oscillations in nonolfactory areas, and respiration-entrained oscillations aid the improvement of cognitive abilities. Given that aerobic exercise increases the rate of respiration and intensity of nasal airflow, this study evaluates the role of OSNs in mediating the effects of aerobic exercise on memory.

Methods: We examined spatial memory following exercise in animal models of olfactory sensory neuron impairment (methimazole injection 300 mg/kg/week).

Results: Destroying OSNs significantly reduces olfactory bulb (OB) activity at delta and theta frequency bands as well as its coupling to respiration. More importantly, it abolished the positive effect of exercise on spatial memory (P<0.05).

Conclusion: The OB activity is one of the probable mechanisms for improving spatial memory following exercise.

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研究嗅觉神经元对有氧运动引起的空间记忆改善的促进作用

导言研究表明，运动对空间记忆和学习有积极影响。嗅觉神经元（OSNs）会对鼻腔气流引起的机械刺激做出反应，这种刺激与气流强度有关。因此，鼻腔呼吸可以调节非嗅觉区域的大脑振荡，而呼吸引起的振荡有助于提高认知能力。鉴于有氧运动会增加呼吸频率和鼻腔气流强度，本研究评估了有氧运动在调解有氧运动对记忆影响中的作用：方法：我们在嗅觉感觉神经元损伤的动物模型（注射甲巯咪唑300毫克/千克/周）中研究了运动后的空间记忆：结果：破坏嗅觉神经元会明显降低嗅球（OB）在δ和θ频段的活动及其与呼吸的耦合。更重要的是，它消除了运动对空间记忆（PC）的积极影响：嗅球活动是运动后改善空间记忆的可能机制之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Basic and Clinical Neuroscience NEUROSCIENCES-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： BCN is an international multidisciplinary journal that publishes editorials, original full-length research articles, short communications, reviews, methodological papers, commentaries, perspectives and “news and reports” in the broad fields of developmental, molecular, cellular, system, computational, behavioral, cognitive, and clinical neuroscience. No area in the neural related sciences is excluded from consideration, although priority is given to studies that provide applied insights into the functioning of the nervous system. BCN aims to advance our understanding of organization and function of the nervous system in health and disease, thereby improving the diagnosis and treatment of neural-related disorders. Manuscripts submitted to BCN should describe novel results generated by experiments that were guided by clearly defined aims or hypotheses. BCN aims to provide serious ties in interdisciplinary communication, accessibility to a broad readership inside Iran and the region and also in all other international academic sites, effective peer review process, and independence from all possible non-scientific interests. BCN also tries to empower national, regional and international collaborative networks in the field of neuroscience in Iran, Middle East, Central Asia and North Africa and to be the voice of the Iranian and regional neuroscience community in the world of neuroscientists. In this way, the journal encourages submission of editorials, review papers, commentaries, methodological notes and perspectives that address this scope.